Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Myeloid-derived suppressor cells in B cell malignancies

Mon Apr 15 17:01:43 2024

(2015) Myeloid-derived suppressor cells in B cell malignancies. Tumor Biology. pp. 7339-7353. ISSN 1010-4283

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Tumor cells use several mechanisms such as soluble immune modulators or suppressive immune cells to evade from anti-tumor responses. Immunomodulatory cytokines, such as transforming growth factor-beta, interleukin (IL)-10, and IL-35, soluble factors, such as adenosine, immunosuppressive cells, such as regulatory T cells, NKT cells and myeloid-derived suppressor cells (MDSCs), are the main orchestra leaders involved in immune suppression in cancer by which tumor cells can freely expand without immune cell-mediated interference. Among them, MDSCs have attracted much attention as they represent a heterogenous population derived from myeloid progenitors that are expanded in tumor condition and can also shift toward other myeloid cells, such as macrophages and dendritic cells, after tumor clearing. MDSCs exert their immunosuppressive effects through various immune and non-immune mechanisms which make them as potent tumor-promoting cells. Although, there are several studies regarding the immunobiology of MDSCs in different solid tumors, little is known about the precise characteristics of these cells in hematological malignancies, particularly B cell malignancies. In this review, we tried to clarify the precise role of MDSCs in B cell-derived malignancies.

Item Type: Article
Mohammadnia-Afrouzi, M.UNSPECIFIED
Ghalamfarsa, G.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: B cell malignancies Lymphoma Leukemia Multiple myeloma Myeloid-derived suppressor cells Immune suppression colony-stimulating factor tumor-bearing mice cd8(+) t-cells multiple-myeloma bone-marrow follicular lymphoma antitumor immunity dendritic cells nitric-oxide l-arginine Oncology
Page Range: pp. 7339-7353
Journal or Publication Title: Tumor Biology
Journal Index: ISI
Volume: 36
Number: 10
Identification Number:
ISSN: 1010-4283
Depositing User: مهندس مهدی شریفی

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