Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms

Sat Jun 25 10:09:21 2022

(2015) Naringenin improves learning and memory in an Alzheimer's disease rat model: Insights into the underlying mechanisms. European Journal of Pharmacology. pp. 195-201. ISSN 0014-2999

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Abstract

Alzheimer's disease (AD) is one of the prevalent neurological disorders of the central nervous system hallmarked by increased beta-amyloid (A beta) deposition and ensuing learning and memory deficit. In the present study, the beneficial effect of naringenin on improvement of learning and memory was evaluated in an Alzheimer's disease rat model. The A beta-injected rats showed a lower alternation score in Y-maze task, impairment of retention and recall capability in passive avoidance test, and lower correct choices and higher errors in radial arm maze (RAM) task as compared to sham group in addition to enhanced oxidative stress and apoptosis. Naringenin, but not a combination of naringenin and fulvestrant (an estrogenic receptor antagonist) significantly improved the performance of A beta-injected rats in passive avoidance and RAM tasks. Naringenin pretreatment of A beta-injected rats also lowered hippocampal malondialdehyde (MDA) with no significant effect on nitrite and superoxide dismutase (SOD) activity in addition to lowering apoptosis. These results suggest naringenin pretreatment attenuates A beta-induced impairment of learning and memory through mitigation of lipid peroxidation and apoptosis and its beneficial effect is somewhat mediated via estrogenic pathway. (C) 2015 Elsevier B.V. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Ghofrani, S.UNSPECIFIED
Joghataei, M. T.UNSPECIFIED
Mohseni, S.UNSPECIFIED
Baluchnejadmojarad, T.UNSPECIFIED
Bagheri, M.UNSPECIFIED
Khamse, S.UNSPECIFIED
Roghani, M.UNSPECIFIED
Keywords: Naringenin Alzheimer's disease Beta-amyloid Learning and memory Oxidative stress Apoptosis oxidative stress diabetic-rats nitric-oxide intracerebroventricular-streptozotocin cognitive impairment signaling pathway brain activation apoptosis deficits Pharmacology & Pharmacy
Divisions:
Page Range: pp. 195-201
Journal or Publication Title: European Journal of Pharmacology
Journal Index: ISI
Volume: 764
Identification Number: https://doi.org/10.1016/j.ejphar.2015.07.001
ISSN: 0014-2999
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/542

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