Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Factor analysis of metabolic syndrome components and predicting type 2 diabetes: Results of 10-year follow-up in a Middle Eastern population

(2015) Factor analysis of metabolic syndrome components and predicting type 2 diabetes: Results of 10-year follow-up in a Middle Eastern population. Journal of Diabetes. pp. 830-838. ISSN 1753-0393

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Abstract

BackgroundThe relationship among components of metabolic syndrome (MetS) and their association with diabetes is unclear in West Asia. The aim of the present study was to conduct factor analysis of MetS components and the effect these factors have on the incidence of type 2 diabetes (T2D) in a population-based cohort study of the Tehran Lipid and Glucose Study (TLGS). MethodsThe present study enrolled 1861 men and 2706 women (20-60 years of age), from Tehran (Iran) who were free of diabetes at baseline and followed them for 10 years. A principal component analysis was performed to extract standardized factors from MetS components. Logistic regression was used to detect associations between the extracted factors and the incidence of diabetes. A propensity score was used to correct differential selection bias resulting from loss to follow-up. ResultsFactor analysis identified three factors (blood pressure, lipids and glycemia). Waist circumference was shared in three all factors. Blood pressure, lipids and glycemia were related to the incidence of diabetes with odds ratios (95 confidence intervals) of 2.23 (1.31-3.78), 1.89 (1.27-3.67), and 7.54 (4.09-13.91), respectively, in men and 2.13 (1.34-3.40), 2.06 (1.35-3.15), and 13.91 (7.29-26.51), respectively, in women for the third versus the first tertile of these standardized factors. ConclusionsCentral adiposity may have a pivotal role in MetS linking other risk factors together. Glycemia had a high impact on the incidence of diabetes, whereas blood pressure and lipid had a similar moderate effect on the incidence of diabetes.

Item Type: Article
Keywords: factor analysis metabolic syndrome Tehran Lipid and Glucose Study (TLGS) type 2 diabetes mellitus confirmatory factor-analysis measured insulin sensitivity cardiovascular risk-factors iranian urban-population adult-population resistance syndrome prevalence glucose definitions disease Endocrinology & Metabolism
Divisions:
Page Range: pp. 830-838
Journal or Publication Title: Journal of Diabetes
Journal Index: ISI
Volume: 7
Number: 6
Identification Number: https://doi.org/10.1111/1753-0407.12252
ISSN: 1753-0393
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/540

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