Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression

Wed May 22 11:26:37 2024

(2018) Effects of Essential Oil of Satureja Bachtiarica Bunge in a Rat Model of Reserpine-Induced Depression. Iranian Journal of Medical Sciences. pp. 409-415. ISSN 0253-0716

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Abstract

Background: Due to the unfavorable side effects of some commonly used chemical drugs, the trend in the public has shifted towards using herbal medicines to treat central nervous system disorders like depression. The present experimental study was designed to evaluate the effect of Marze (Satureja bachtiarica Bunge) essential oil on reserpine-induced depression in rats. Methods: In total, 48 male Wistar rats were randomly divided into 6 groups: 1) control, 2) reserpine, 3-5) reserpine with 50, 75 and 100 mg/kg of Marze essential oil, respectively, and 6) reserpine and fluoxetine. The forced swimming test was used to evaluate the antidepressant activity of the essential oil. Total antioxidant capacity (TAC) and MDA levels of serum and brain were also determined. Results: Reserpine induced a significant increase in the immobility time of rats in the forced swimming test (P=0.02) and treatment with Marze essential oil (50, 100 mg/kg) ameliorated the reserpine induced changes (P=0.04, P=0.03, respectively). Reserpine-induced reduction in brain TCA was improved using Marze essential oil at a dose of 100 mg/kg (P=0.04). Marze essential oil at 100 mg/kg dose significantly decreased the MDA level in the brain tissues of reserpine-treated rats (P=0.04). Conclusion: Marze (Satureja bachtiarica Bunge) essential oil has the ability to prevent depression induced by reserpine probably via its antioxidant activity.

Item Type: Article
Creators:
CreatorsEmail
Bakhtiarpoor, M.UNSPECIFIED
Setorki, M.UNSPECIFIED
Kaffashian, M. R.UNSPECIFIED
Keywords: Satureja bachtiarica Bunge Marze Antidepressant activity Antioxidant activity Forced swim test alzheimers-disease carvacrol 5-isopropyl-2-methylphenol chemical-composition oxidative stress mice involvement disorders extract impairment memory plants General & Internal Medicine
Divisions:
Page Range: pp. 409-415
Journal or Publication Title: Iranian Journal of Medical Sciences
Journal Index: ISI
Volume: 43
Number: 4
ISSN: 0253-0716
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/51

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