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Ilam University of Medical Sciences

Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with beta-Thalassemia major

Thu Sep 29 09:07:59 2022

(2016) Assessment of Liver and Kidney Functional Parameters along with oxidative Stress and Inflammatory Biomarker in Patients with beta-Thalassemia major. Iranian Journal of Pediatric Hematology and Oncology. pp. 248-259. ISSN 2008-8892

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Abstract

Background: Thalassemias are the most common inherited blood disorders caused by some mutations which can reduce the synthesis of globin chains. Iron overload and its organ deposition are responsible for functional abnormalities and tissue injury in patients who affected by beta-thalassemia major. The aim of this case-control study was evaluation of hematological parameters, oxidative stress and some serum liver and kidney risk factors which play crucial role for early prediction and prevention of patients to end-stage tissue failure and mortality. Materials and Methods: Present study consisted of Fifty young adult subjects with beta-thalassemia major (beta-TM) (aged<18 years) and same number age and sex- matched healthy subjects as control group. Hematological and biochemical laboratory parameters included Urea, Creatinine, Uric Acid, Aspartate Aminotransferase (AST), Alanine transaminase (ALT), Alkaline phosphatase (ALP) (pars azmoon kit), oxidative stress biomarker PAB, giving a redox index (chemically), and serum high-sensitivity C-reactive protein (hs-CRP) were evaluated. Results: Urea, Creatinine and Uric Acid were significantly decreased in patients group (P<0.001), in spite of, serum ferritin, liver biomarkers AST, ALT, ALP and risk factor biomarker PAB were statistically increased in patients versus control group(P<0.001), whereas hs-CRP(P>0.05) was not significantly difference in study groups. Exception hs-CRP and PAB (P>0.05), liver risk factors had a positive correlation with ferritin and serum Urea, Creatinine and Uric Acid tests had negative meaningful with hematological parameters (P<0.001). Likewise, PAB with AST showed a positive correlation (P<0.001) and irreversibly with urea and creatinine (P<0.001). We did not find a slight correlation between hs-CRP in the company to hematological and biochemical laboratory finding (P>0.05). Conclusion: Higher level of risk factors PAB values and key liver enzyme profiles are able to involve in the prognostic pathological consequences in patients with beta-thalassemia major. Even so, they contribute toward the gradual development of tissue injuries.

Item Type: Article
Creators:
CreatorsEmail
Shanaki, M.UNSPECIFIED
Ehteram, H.UNSPECIFIED
Nasiri, H.UNSPECIFIED
Azad, M.UNSPECIFIED
Kouhkan, F.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Mobarra, N.UNSPECIFIED
Keywords: Beta-thalassemia major kidney live Inflammatory Oxidative stress c-reactive protein prooxidant-antioxidant balance transfusional iron overload sickle-cell-disease desferrioxamine complications nephropathy fibrosis children injury Pediatrics
Divisions:
Page Range: pp. 248-259
Journal or Publication Title: Iranian Journal of Pediatric Hematology and Oncology
Journal Index: ISI
Volume: 6
Number: 4
ISSN: 2008-8892
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/506

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