Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer

Mon Mar 4 09:28:26 2024

(2016) Circulating levels of the miRNAs, miR-194, and miR-29b, as clinically useful biomarkers for colorectal cancer. Tumor Biology. pp. 1781-1788. ISSN 1010-4283

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Abstract

The microRNAs (miRNAs), miR-194 and miR-29b, have been shown to downregulate in colorectal cancer (CRC) and may identify and classify CRC patients as compared with those in control subjects. In the current study, we aimed to explore whether the serum levels of the miRNAs could be potential biomarkers for diagnosis and prognosis of CRC. A quantitative reverse-transcription polymerase chain reaction (qRT-PCR) assay was utilized to determine and compare serum levels of miR-194 and miR-29b in 55 patients with CRC and 55 control subjects. The correlations between levels of the miRNAs and clinicopathological stages of cancer were analyzed in patients. Receiver operating characteristic (ROC) curve and survival analyses were carried out, respectively, to determine diagnostic and prognostic values of the miRNAs. Serum levels of miR-194 and miR-29b were found to be significantly lower in CRC patients than those in control subjects (P < 0.0001). Moreover, serum levels of the miRNAs in patients were inversely correlated with the advanced TNM stages (P = 0.01). ROC curve and survival analyses revealed that reduced levels of the miRNAs could serve as diagnostic and prognostic biomarkers for patients with CRC (P = 0.0001). Serum levels of miR-194 and miR-29b may serve as potential biomarkers for diagnosis and prognosis of CRC.

Item Type: Article
Creators:
CreatorsEmail
Basati, G.UNSPECIFIED
Razavi, A. E.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Malayeri, F. A.UNSPECIFIED
Keywords: Serum miR-194 miR-29b Colorectal cancer TNM staging qRT-PCR renal-cell carcinoma mesenchymal transition micrornas expression leukemia pcr Oncology
Divisions:
Page Range: pp. 1781-1788
Journal or Publication Title: Tumor Biology
Journal Index: ISI
Volume: 37
Number: 2
Identification Number: https://doi.org/10.1007/s13277-015-3967-0
ISSN: 1010-4283
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/491

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