Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats

Mon Oct 3 04:58:27 2022

(2016) Perfluorocarbon attenuates inflammatory cytokines, oxidative stress and histopathologic changes in paraquat-induced acute lung injury in rats. Environmental Toxicology and Pharmacology. pp. 9-15. ISSN 1382-6689

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Abstract

The effects of perfluorocarbon (PFC) on paraquat (PQ) induced acute lung injury (ALI) was evaluated among rats. Twenty four Wistar rats were divided into 4 groups: control group injected by saline physiologic 0.9, PFC group injected by Perfluorocarbon, PQ group injected by PQ and PQ+ PFC group injected by PFC one hour after receiving paraquat. Bronchoalveular fluid content, inflammatory cytokines, oxidative and histopathologic changes were measured after 72 h. The levels of interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta(TGF-beta 1) in the PQ group were increased compared to either control or PFC groups, but their levels decreased in PQ+ PFC group significantly (p <0.05). Also, histopathologic evaluation revealed an increase in malondialdehyde (MDA) and hydroxyproline (HP) in the PQ group but a decrease in PQ+PFC group significantly (p < 0.01). PFC emulsion by its anti-inflammatory, anti-oxidative and anti-fibrotic properties can reduce the inflammatory and fibrotic alterations, pulmonary oedema, and pulmonary histopathologic changes created by PQ (C)2015 Elsevier B.V. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Khalighi, Z.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Cheraghi, J.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Soleimannejad, K.UNSPECIFIED
Asadollahi, R.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Keywords: Lung Paraquat Perfluorocarbon Inflammation Malondealdehyde Histopathology induced pulmonary-fibrosis alveolar epithelial-cells mice reperfusion activation inhalation induction ischemia model Environmental Sciences & Ecology Pharmacology & Pharmacy Toxicology
Divisions:
Page Range: pp. 9-15
Journal or Publication Title: Environmental Toxicology and Pharmacology
Journal Index: ISI
Volume: 42
Identification Number: https://doi.org/10.1016/j.etap.2015.12.002
ISSN: 1382-6689
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/486

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