Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

A review of animal models of Alzheimer's disease: a brief insight into pharmacologic and genetic models

Thu Feb 22 20:34:02 2024

(2016) A review of animal models of Alzheimer's disease: a brief insight into pharmacologic and genetic models. Physiology and Pharmacology. pp. 5-11. ISSN 2476-5236

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Abstract

Alzheimer's disease (AD) is the most common form of neurodegenerative disorders. Memory loss in an alert person and impairment in the function of language, attention, perception, judgment or problem solving can occur in patients with AD. However, there are some medications in order to delay the debilitating aspects of the disease; but unfortunately, scientists could not found approaches to cure this progressive problem. Hence, in order to investigate the exact mechanisms underlying the disease and to discover novel drugs that can slow the progress or alleviate the clinical symptoms of AD, producing a model which can express the most pathophysiologic and behavioral features of the disease is a desire. Nowadays, there are different animal models developed by use of pharmacologic agents and/or genetic manipulations. In this paper, we aimed to describe different animal models of AD, genetic and pharmacologic, that are mostly used by researchers.

Item Type: Article
Creators:
CreatorsEmail
Salari, S.UNSPECIFIED
Bagheri, M.UNSPECIFIED
Keywords: Alzheimer's disease Animal model Pharmacologic model Genetic model beta-amyloid protein a-beta rat model mouse models neurofibrillary degeneration transgenic mice truncated tau in-vivo memory neurodegeneration Physiology
Divisions:
Page Range: pp. 5-11
Journal or Publication Title: Physiology and Pharmacology
Journal Index: ISI
Volume: 20
Number: 1
ISSN: 2476-5236
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/483

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