Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Alterations in Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-Induced Diabetic Rats: Effects of Trigonella foenum-graecum Extract and Swimming Training

Thu Apr 18 23:44:11 2024

(2016) Alterations in Plasma Glucose and Cardiac Antioxidant Enzymes Activity in Streptozotocin-Induced Diabetic Rats: Effects of Trigonella foenum-graecum Extract and Swimming Training. Canadian Journal of Diabetes. pp. 135-142. ISSN 1499-2671

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Abstract

Objectives: Diabetes mellitus is a group of metabolic diseases characterized by chronic hyperglycemia. Trigonella Tomlin-gamin( (fenugreek) and swimming training have previously been reported to have hypoglycemic and antioxidant effects. We aimed to evaluate the effects of swimming training and fenugreek aqueous extract, alone and in combination, on plasma glucose and cardiac antioxidant enzymes activity of streptozotocin-induced diabetes in rats. Methods: We divided 70 male Wistar rats equally into 7 groups: diabetic control (DC), healthy control (FIC), swimming (5), fenugreek seed extract (1.74 g/kg) (Fl), fenugreek seed extract (0.87 g/kg) (F2), swimming + fenugreek seed extract (1.74 glkg) (5F1), and swimming+ fenugreek seed extract (0.87 glkg) (SF2). We used streptozotocin for the induction of diabetes. Statistical analyses were performed using the statistical program SPSS. Results: We did not detect any significant differences in body weight in the Fl, F2, S, SF1 and SF2 groups compared with the DC group (p>0.05). The results also revealed that the hypoglycemic effect of combined swimming and fenugreek was significantly stronger (p<0.05) than either of those alone. The Fl, 5, SF1 and SF2 groups showed improved superoxide dismutase activity with respect to the DC group (p<0.05). Catalase activity in the Fl, S, SF1 and SF2 groups were significantly higher than those of the DC group (p<0.05). Glutathione peroxidase activity in the S, SF1 and SF2 groups were significantly increased corn pared with the DC group (p<0.05). Conclusions: Our findings suggest that the combination of fenugreek seed extract and swimming could be useful for the treatment of hyperglycemia and cardiac oxidative stress induced by type 1 diabetes mellitus. (C) 2016 Canadian Diabetes Association. Published by Elsevier Inc. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Haghani, K.UNSPECIFIED
Bakhtiyari, S.UNSPECIFIED
Mohammadpour, J. D.UNSPECIFIED
Keywords: Endurance Fenugreek Heart antioxidants Swimming training Type 1 diabetes oxidative stress fenugreek seeds blood-glucose aqueous extract tissue-damage exercise heart endurance system homeostasis Endocrinology & Metabolism
Divisions:
Page Range: pp. 135-142
Journal or Publication Title: Canadian Journal of Diabetes
Journal Index: ISI
Volume: 40
Number: 2
Identification Number: https://doi.org/10.1016/j.jcjd.2015.08.012
ISSN: 1499-2671
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/476

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