Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis

Tue Oct 4 00:23:38 2022

(2016) IL-21 and IL-21 receptor in the immunopathogenesis of multiple sclerosis. Journal of Immunotoxicology. pp. 274-285. ISSN 1547-691X

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Abstract

Cytokines are considered important factors in the modulation of various immune responses. Among them, interleukin (IL)-21 is one of the major immune modulators, adjusting various immune responses by affecting various immune cells. It has been suggested that IL-21 may enhance autoimmunity through different mechanisms, such as development and activation of helper T (T-H)-17 and follicular helper T (T-FH) cells, activation of natural killer (NK) cells, enhancing B-cell differentiation and antibody secretion and suppression of regulatory T (T-reg) cells. Moreover, IL-21 has also been suggested to be an inducer of autoimmunity when following treatment of MS patients with some therapeutics such as alemtuzumab. This review will seek to clarify the precise role of IL-21/IL-21R in the pathogenesis of MS and, in its animal model, experimental autoimmune encephalomyelitis (EAE).

Item Type: Article
Creators:
CreatorsEmail
Ghalamfarsa, G.UNSPECIFIED
Mahmoudi, M.UNSPECIFIED
Mohammadnia-Afrouzi, M.UNSPECIFIED
Yazdani, Y.UNSPECIFIED
Anvari, E.UNSPECIFIED
Hadinia, A.UNSPECIFIED
Ghanbari, A.UNSPECIFIED
Setayesh, M.UNSPECIFIED
Yousefi, M.UNSPECIFIED
Jadidi-Niaragh, F.UNSPECIFIED
Keywords: Interleukin (IL)-21 IL-21 receptor multiple sclerosis pathogenesis experimental autoimmune encephalomyelitis chronic lymphocytic-leukemia central-nervous-system regulatory t-cells b-cells th17 cells nk cells neuromyelitis-optica dendritic cells disease progression Toxicology
Divisions:
Page Range: pp. 274-285
Journal or Publication Title: Journal of Immunotoxicology
Journal Index: ISI
Volume: 13
Number: 3
Identification Number: https://doi.org/10.3109/1547691x.2015.1089343
ISSN: 1547-691X
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/468

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