Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association between serum levels of high sensitive C-reactive protein and inflammation activity in chronic gastritis patients

Sun Sep 25 11:00:20 2022

(2016) Association between serum levels of high sensitive C-reactive protein and inflammation activity in chronic gastritis patients. Scandinavian Journal of Gastroenterology. pp. 531-537. ISSN 0036-5521

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Abstract

Background Gastritis is an important premalignant lesion and recent studies suggested a production of inflammatory cytokine-like C-reactive protein during gastritis. This study aimed to determine any relationship between high sensitive C-reactive protein (hs-CRP) and inflammation activity among patients with gastritis. Methods Demographic and clinical variables of participants were collected by a validated questionnaire. Using histology of the gastric mucosa, Helicobacter pylori status was investigated and serum concentrations of hs-CRP were measured among dyspeptic patients. Correlation between hs-CRP serum levels and inflammation activities was evaluated by logistic regression analysis. The relation between active inflammation and other variables was evaluated by logic link function model. Results Totally 239 patients (56.6 female) were analysed. The prevalence of mild, moderate and severe inflammation activities was 66.5, 23.8 and 9.6 respectively. Mean +/- SD of hs-CRP among men and women were 2.85 +/- 2.84mg/dl and 2.80 +/- 4.80mg/dl (p=0.047) respectively. Mean +/- SD of hs-CRP among patients with H. pylori infection, gland atrophy, metaplasia and dysplasia were 2.83 +/- 3.80mg/dl, 3.52 +/- 5.1mg/dl, 2.22 +/- 2.3mg/dl and 5.3 +/- 5.04mg/dl respectively. Relationship between hs-CRP and inflammation activities (p<0.01) was significant. A significant relationship between dysplasia and hs-CRP (p<0.04) was revealed. A significant relationship between age and hs-CRP was detected (p<0.05). Conclusion Although serum hs-CRP is not a specific biomarker for gastritis, elevated hs-CRP levels may be considered as a predictive marker of changes in gastric mucosa and a promising therapeutic target for patients with gastritis.

Item Type: Article
Creators:
CreatorsEmail
Rahmani, A.UNSPECIFIED
Moradkhani, A.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Heirdarlo, A. J.UNSPECIFIED
Abangah, G.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Sayehmiri, K.UNSPECIFIED
Keywords: Chronic gastritis Helicobacter pylori hs-CRP inflammation activities helicobacter-pylori infection binding-protein follow-up cancer risk Gastroenterology & Hepatology
Divisions:
Page Range: pp. 531-537
Journal or Publication Title: Scandinavian Journal of Gastroenterology
Journal Index: ISI
Volume: 51
Number: 5
Identification Number: https://doi.org/10.3109/00365521.2015.1102318
ISSN: 0036-5521
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/465

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