Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Combination therapy of curcumin an alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis

Wed Jun 29 11:42:39 2022

(2018) Combination therapy of curcumin an alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis. Archives of Endocrinology Metabolism. pp. 438-445. ISSN 2359-3997

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Abstract

Objective: This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. Subjects and methods: In a randomized, double-blind trial study, 60 postmenopausal women were divided into three groups: control, alendronate, and alendronate + curcumin. Each group included 20 patients. Total body, total hip, lumbar spine and femoral neck BMDs were measured by dual-energy X-ray absorptiometry (DXA) at baseline and after 12 months of therapy. Bone turnover markers such as bone-specific alkaline phosphatase (BALP), osteocalcin and C-terminal cross-linking telopeptide of type I collagen (CTx) were measured at the outset and 6 months later. Results: Patients in the control group suffered a significant decrease in BMD and increased bone turnover markers at the end of study.The group treated with only alendronate showed significantly decreased levels of BALP and CTx and increased levels of osteocalcin compared to the control group.The alendronate group also showed significant increases in the total body, total hip, lumbar spine and femoral neck BMDs at the end of study compared to the control group. In the curcumin + alendronate group, BALP and CTx levels decreased and osteocalcin levels increased significantly at the end of study compared to the control and alendronate groups. BMD indexes also increased in four areas significantly at the end of study compared to the control and alendronate groups. Conclusion: The combination of curcumin and alendronate has beneficial effects on BMD and bone turnover markers among postmenopausal women with osteoporosis.

Item Type: Article
Creators:
CreatorsEmail
Khanizadeh, F.UNSPECIFIED
Rahmani, A.UNSPECIFIED
Asadollahi, K.UNSPECIFIED
Ahmadi, M. R. H.UNSPECIFIED
Keywords: Post menopause osteoporosis alendronate curcumin bone mineral density ovariectomized rat japanese women experience risk osteoclastogenesis microarchitecture activation raloxifene calcitonin ligand Endocrinology & Metabolism
Divisions:
Page Range: pp. 438-445
Journal or Publication Title: Archives of Endocrinology Metabolism
Journal Index: ISI
Volume: 62
Number: 4
Identification Number: https://doi.org/10.20945/2359-3997000000060
ISSN: 2359-3997
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/46

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