Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of Statin Therapy on Clinical Outcomes in Covid-19 Patients: An Updated Systematic Review and Meta-Analysis on All Related Evidences

Thu Feb 22 22:04:55 2024

(2022) Association of Statin Therapy on Clinical Outcomes in Covid-19 Patients: An Updated Systematic Review and Meta-Analysis on All Related Evidences. Journal of Biostatistics and Epidemiology. pp. 407-434. ISSN 23834196 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Introduction: Statins is a class of lipid-lowering drugs and our previous investigations showed that statins have antiviral effects and have a wound healing effect in the lung. This systematic review and meta-analysis aimed to evaluate the effects of statin therapy on mortality and clinical outcomes in COVID-19 patients. Methods: A comprehensive search was conducted in international databases, including MEDLINE, Scopus, Web of Science, and Embase from December 1, 2019 until January 26, 2022 without any restriction in language. The random-effects model was used to estimate the pooled odds ratio (OR). Results: The statin therapy overally was associated with decrease in odds of ventilation pooled OR (95% CI): 0.85 (0.70 to 0.99) and mortality pooled OR (95% CI): 0.73 (0.66 to 0.81) but had no effects on the ICU admission pooled OR (95% CI): 0.93 (0.77 to 1.12), oxygen therapy pooled OR (95% CI): 0.85 (0.70 to 0.99), recovery pooled OR (95% CI): 1.85 (0.35 to 9.92), kidney failure pooled OR (95% CI): 1.01 (0.73 to 1.40), hospitalization pooled OR (95% CI): 1.45 (0.88 to 2.36), asymptomatic disease pooled OR (95% CI): 1.33 (0.24 to 7.44), and ARDS pooled OR (95% CI): 1.15 (0.88 to 1.49). Conclusion: The present meta-analysis showed that statin therapy was associated with a reduced risk of mortality and ventilation in patients with COVID-19 but had no effects on other clinical outcomes. © 2022 Tehran University of Medical Sciences. Published by Tehran University of Medical Sciences.

Item Type: Article
Creators:
CreatorsEmail
Kurd, D. M.UNSPECIFIED
Seidkhani-Nahal, A.UNSPECIFIED
Noori-Zadeh, A.UNSPECIFIED
Sheikhabbasi, A.UNSPECIFIED
Heydari, F.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Keywords: Clinical outcome COVID-19 Meta-Analysis Mortality Statin therapy Systematic Review
Divisions:
Page Range: pp. 407-434
Journal or Publication Title: Journal of Biostatistics and Epidemiology
Journal Index: Scopus
Volume: 8
Number: 4
ISSN: 23834196 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4556

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