Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Efficacy of Atorvastatin and Rosuvastatin on the Changes of alpha and beta Apolipoproteins; A Systematic Review and Meta-Analysis

Sun Mar 3 12:31:37 2024

(2023) The Efficacy of Atorvastatin and Rosuvastatin on the Changes of alpha and beta Apolipoproteins; A Systematic Review and Meta-Analysis. Journal of Advances in Medical and Biomedical Research. pp. 109-116. ISSN 26766264 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Background & Objective: Vascular stenosis is one of the causes of cardiovascular diseases (CVDs). Implementing appropriate therapeutic measures for CVDs requires preventing the progression of stenosis. The purpose of this study was to evaluate the efficacy of atorvastatin and rosuvastatin on the levels of alpha and beta apolipoproteins using systematic review and meta-analysis. Materials & Methods: This review was performed based on the PRISMA protocol. The ISI, Cochrane Library, Google Scholar, PubMed, and Scopus databases were independently searched by two researchers. MeSH keywords were used to recruit related articles published between 2005 and 2018. Meta-analysis was conducted in STATA 11.1software. Results: A total of 65 articles were found. Out of these, nine studies were ultimately included in meta-analysis. The findings showed that alpha lipoprotein level increased by 4.24 mg/dl (95 CI:-0.03;-8.45) and 8.71 mg/dl (95 CI:-1.95;-15.48) in patients treated with atorvastatin and rosuvastatin, respectively. Also, patients treated with either atorvastatin or rosuvastatin showed 40.55mg/dl (95 CI: 32.16; 45.93) and 44.78 g/dl (95 CI: 34.16; 55.39) decreases in beta-lipoprotein levels, respectively. Conclusion: According to the results, rosuvastatin is more effective than atorvastatin in reducing alpha apolipoprotein and increasing beta apolipoprotein levels within a short period of time. © 2023, Zanjan University of Medical Sciences and Health Services. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Sayehmiri, K.UNSPECIFIED
Norozi, S.UNSPECIFIED
Tavan, H.UNSPECIFIED
Keywords: Alphaapolipoprotein Atorvastatin Beta apolipoprotein Meta-analysis Rosuvastatin Systematic review apolipoprotein A apolipoprotein B Article cell heterogeneity drug efficacy geographic distribution human meta analysis quality control risk assessment
Divisions:
Page Range: pp. 109-116
Journal or Publication Title: Journal of Advances in Medical and Biomedical Research
Journal Index: Scopus
Volume: 31
Number: 145
Identification Number: https://doi.org/10.30699/jambs.31.145.109
ISSN: 26766264 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4534

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