Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Amelioration of amyloid beta (Aβ1-40) neurotoxicity by administration of silibinin; a behavioral and biochemical assessment

Mon Feb 26 04:23:35 2024

(2023) Amelioration of amyloid beta (Aβ1-40) neurotoxicity by administration of silibinin; a behavioral and biochemical assessment. Iranian Journal of Basic Medical Sciences. pp. 791-798. ISSN 20083866 (ISSN)

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Objective(s): Alzheimer's disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression. Herbal remedies are considered by many in the community as a natural and safe treatment with fewer side effects. Silibinin, the active ingredient of Silybum marionum, has anti-oxidant, neurotrophic and neuroprotective characteristics. Therefore, here, the effect of different doses of Silibinin extract on oxidative stress and expression of neurotrophic factors was investigated. Materials and Methods: Forty eight male Wistar rats were randomly divided into sham, lesion; Aβ1-40injection, lesion-treatment; Aβ1-40injection followed by different doses of silibinin (50, 100, 200 mg / kg) through gavage and lesion-vehicle group; Aβ1-40injection + vehicle of silibinin. Morris water Maze (MWM) was done 28 days after the last treatment. Hippocampal tissue was removed for biochemical analysis. Production of nitric oxide (NO) and reactive oxygen species (ROS), expression of BDNF/VEGF and cell viability were measured using Griess, fluorimetry, Western blotting and MTT techniques. Results: Different concentrations of silibinin improved behavioral performance in animals. Higher doses of Silibinin could improve memory and learning function through MWM. Also, increasing the concentration of silibinin resulted in decreased ROS and NO production in a dose-dependent manner. Conclusion: Consequently, silibinin may act as a potential candidate for alleviating symptoms of AD. © 2023 Mashhad University of Medical Sciences. All rights reserved.

Item Type: Article
Alihosseini, T.UNSPECIFIED
Mohammadpour, S.UNSPECIFIED
Keywords: Alzheimer's disease Amyloid BDNF Oxidative stress Silibinin VEGF amyloid beta protein1-40 brain derived neurotrophic factor ketamine neurotrophic factor nitric oxide reactive oxygen metabolite vasculotropin xylazine Alzheimer disease animal experiment animal model antioxidant activity Article behavior assessment biochemical analysis cell viability controlled study cytotoxicity dementia dentate gyrus disease exacerbation experimental behavioral test fluorometry hippocampal CA1 region hippocampal CA3 region hippocampal tissue in vivo study learning male memory Morris water maze test MTT assay neuroprotection neurotoxicity Nissl staining nonhuman protein expression rat Silybum marianum Western blotting Wistar rat
Page Range: pp. 791-798
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: Scopus
Volume: 26
Number: 7
Identification Number:
ISSN: 20083866 (ISSN)
Depositing User: مهندس مهدی شریفی

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