Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Bacterial Persister Cells: Mechanisms of Formation, Control, and Eradication

Sat Apr 20 02:39:12 2024

(2023) Bacterial Persister Cells: Mechanisms of Formation, Control, and Eradication. Infectious disorders drug targets. pp. 17-28. ISSN 2212-3989 (Electronic) 1871-5265 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/37170999

Abstract

Bacterial Persister Cells (BPCs) are quiescent, slow-growing or growth-arrested phenotypic variants of normal bacterial cells that are transiently tolerant to antibiotics. It seems that persister cells are the main cause of the recurrence of various chronic infections. Stress response (RpoS-mediated), Toxin-Antitoxin (TA) systems, inhibition of ATP production, Reactive Oxygen Species (ROS), efflux pumps, bacterial SOS response, cell-to-cell communication and stringent response (ppGpp- mediated) are the primary potential mechanisms for persistence cell formation. However, eradicating persistent cells is challenging as the specific molecular mechanisms that initiate their formation remain fuzzy and unknown. Here we reviewed and summarized the current understanding of how bacterial persister cells are formed, controlled, and destroyed.

Item Type: Article
Creators:
CreatorsEmail
Kouhsari, E.UNSPECIFIED
Kaviar, V. H.UNSPECIFIED
Asadi, A.UNSPECIFIED
Ahmadi, A.UNSPECIFIED
Sholeh, M.UNSPECIFIED
Mirbalouchzehi, A.UNSPECIFIED
Yaghoubi, S.UNSPECIFIED
Abdi, M.UNSPECIFIED
Keywords: Humans *Anti-Bacterial Agents/pharmacology/therapeutic use *Bacteria Persister cells bacterial cells chronic infections eradication formation phenotypic variants
Divisions:
Page Range: pp. 17-28
Journal or Publication Title: Infectious disorders drug targets
Journal Index: Pubmed
Volume: 23
Number: 7
Identification Number: https://doi.org/10.2174/1871526523666230511142054
ISSN: 2212-3989 (Electronic) 1871-5265 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4514

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