Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance

Fri Jun 14 00:43:26 2024

(2023) microRNA-382 as a tumor suppressor? Roles in tumorigenesis and clinical significance. International journal of biological macromolecules. p. 125863. ISSN 1879-0003 (Electronic) 0141-8130 (Linking)

Full text not available from this repository.

Official URL: https://www.ncbi.nlm.nih.gov/pubmed/37467828

Abstract

MicroRNAs (miRNAs) are small single-stranded RNAs belonging to a class of non-coding RNAs with an average length of 18-22 nucleotides. Although not able to encode any protein, miRNAs are vastly studied and found to play role in various human physiologic as well as pathological conditions. A huge number of miRNAs have been identified in human cells whose expression is straightly regulated with crucial biological functions, while this number is constantly increasing. miRNAs are particularly studied in cancers, where they either can act with oncogenic function (oncomiRs) or tumor-suppressors role (referred as tumor-suppressor/oncorepressor miRNAs). miR-382 is a well-studied miRNA, which is revealed to play regulatory roles in physiological processes like osteogenic differentiation, hematopoietic stem cell differentiation and normal hematopoiesis, and liver progenitor cell differentiation. Notably, miR-382 deregulation is reported in pathologic conditions, such as renal fibrosis, muscular dystrophies, Rett syndrome, epidural fibrosis, atrial fibrillation, amelogenesis imperfecta, oxidative stress, human immunodeficiency virus (HIV) replication, and various types of cancers. The majority of oncogenesis studies have claimed miR-382 downregulation in cancers and suppressor impact on malignant phenotype of cancer cells in vitro and in vivo, while a few studies suggest opposite findings. Given the putative role of this miRNA in regulation of oncogenesis, assessment of miR-382 expression is suggested in a several clinical investigations as a prognostic/diagnostic biomarker for cancer patients. In this review, we have an overview to recent studies evaluated the role of miR-382 in oncogenesis as well as its clinical potential.

Item Type: Article
Creators:
CreatorsEmail
Fattahi, M.UNSPECIFIED
Shahrabi, S.UNSPECIFIED
Saadatpour, F.UNSPECIFIED
Rezaee, D.UNSPECIFIED
Beyglu, Z.UNSPECIFIED
Delavari, S.UNSPECIFIED
Amrolahi, A.UNSPECIFIED
Ahmadi, S.UNSPECIFIED
Bagheri-Mohammadi, S.UNSPECIFIED
Noori, E.UNSPECIFIED
Majidpoor, J.UNSPECIFIED
Nouri, S.UNSPECIFIED
Aghaei-Zarch, S. M.UNSPECIFIED
Falahi, S.UNSPECIFIED
Najafi, S.UNSPECIFIED
Le, B. N.UNSPECIFIED
Keywords: Biomarker Cancer miR-382 miRNA microRNA
Divisions:
Page Range: p. 125863
Journal or Publication Title: International journal of biological macromolecules
Journal Index: Pubmed
Volume: 250
Identification Number: https://doi.org/10.1016/j.ijbiomac.2023.125863
ISSN: 1879-0003 (Electronic) 0141-8130 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4506

Actions (login required)

View Item View Item