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Ilam University of Medical Sciences

An updated systematic review and dose-response meta-analysis on the relation between exposure to arsenic and risk of type 2 diabetes

Mon Jul 15 16:57:54 2024

(2023) An updated systematic review and dose-response meta-analysis on the relation between exposure to arsenic and risk of type 2 diabetes. Toxicology letters. pp. 115-127. ISSN 1879-3169 (Electronic) 0378-4274 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/37562716

Abstract

Arsenic is among the most critical environmental toxicants associated with many human disorders. However, its effect on type 2 diabetes mellitus (T2DM) is contradictory. This systematic review and dose-response meta-analysis aim to update information on the association between arsenic exposure and the risk of T2DM. The sample type (drinking water, urine, blood, and nails) conducted the subgroup analysis. Evaluation of the high vs. low arsenic concentrations showed a significant association between drinking water arsenic (OR: 1.58, 95 CI: 1.20-2.08) and urinary arsenic (OR: 1.37, 95 CI: 1.24-1.51) with the risk of T2DM. The linear dose-response meta-analysis showed that each 1 mug/L increase in levels of drinking water arsenic (OR: 1.01, 95 CI: 1.00-1.01) and urinary arsenic (OR: 1.01, 95 CI: 1.00-1.02) was associated with a 1 increased risk of T2DM. The non-linear dose-response analysis indicated that arsenic in urine was associated with the risk of T2DM ((Pnon-linearity)<0.001). However, this effect was not statistically significant for arsenic in drinking water ((Pnon-linearity)=0.941). Our findings suggest that blood arsenic was not significantly linked to the increased risk of T2DM in high vs. low (OR: 1.21, 95 CI: 0.85-1.71), linear (OR: 1.04, 95 CI: 0.99-1.09), and non-linear (P(non-linearity)=0.365) analysis. Also, nail arsenic was not associated with the risk of T2DM in this meta-analysis (OR: 1.33, 95 CI: 0.69-2.59). This updated dose-response meta-analysis indicated that arsenic exposure was significantly correlated with the risk of T2DM.

Item Type: Article
Creators:
CreatorsEmail
Rahimi Kakavandi, N.UNSPECIFIED
Mousavi, T.UNSPECIFIED
Asadi, T.UNSPECIFIED
Moradi, A.UNSPECIFIED
Esmaeili, M.UNSPECIFIED
Habibian Sezavar, A.UNSPECIFIED
Nikfar, S.UNSPECIFIED
Abdollahi, M.UNSPECIFIED
Keywords: Humans *Diabetes Mellitus, Type 2/chemically induced/epidemiology *Arsenic/toxicity *Drinking Water/adverse effects/analysis *Water Pollutants, Chemical/toxicity/analysis Environmental Exposure/adverse effects/analysis Arsenic Diabetes mellitus Meta-analysis Systematic review T2DM competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Divisions:
Page Range: pp. 115-127
Journal or Publication Title: Toxicology letters
Journal Index: Pubmed
Volume: 384
Identification Number: https://doi.org/10.1016/j.toxlet.2023.08.001
ISSN: 1879-3169 (Electronic) 0378-4274 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4503

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