Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer

Mon Jun 24 03:28:05 2024

(2023) The role of microRNA-185 in the pathogenesis of human diseases: A focus on cancer. Pathology, research and practice. p. 154729. ISSN 1618-0631 (Electronic) 0344-0338 (Linking)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/37639952

Abstract

MicroRNAs (miRNAs) are a widely-studied class of non-coding RNAs characterized by their short length (18-25 nucleotides). The precise functions of miRNAs are not well-elucidated; however, an increasing number of studies suggest their involvement in various physiologic processes and deregulation in pathologic conditions. miRNA-185 (miR-185) is among the mostly-studied miRNAs in human diseases, which is found to play putative roles in conditions like metabolic disorders, asthma, frailty, schizophrenia, and hepatitis. Notably, many cancer studies report the downregulation of miR-185 in cell lines, tumor tissues, and plasma specimens of patients, while it demonstrates a suppressing role on the malignant properties of cancer cells in vitro and in vivo. Accordingly, miR-185 can be considered a tumor suppressor miRNA in human malignancies, while a few studies also report inconsistent findings. Being suggested as a prognostic/diagnostic biomarker, mi-185 is also found to offer clinical potentials, particularly for early diagnosis and prediction of the prognosis of cancer patients. In this review, we have outlined the studies that have evaluated the functions and clinical significance of miR-185 in different human diseases with a particular focus on cancer.

Item Type: Article
Creators:
CreatorsEmail
Pordel, S.UNSPECIFIED
Khorrami, M.UNSPECIFIED
Saadatpour, F.UNSPECIFIED
Rezaee, D.UNSPECIFIED
Cho, W. C.UNSPECIFIED
Jahani, S.UNSPECIFIED
Aghaei-Zarch, S. M.UNSPECIFIED
Hashemi, E.UNSPECIFIED
Najafi, S.UNSPECIFIED
Keywords: Humans *MicroRNAs/genetics *Neoplasms/genetics Cell Line Clinical Relevance Down-Regulation Biomarker Cancer MiR-185 MicroRNA MicroRNA-185
Divisions:
Page Range: p. 154729
Journal or Publication Title: Pathology, research and practice
Journal Index: Pubmed
Volume: 249
Identification Number: https://doi.org/10.1016/j.prp.2023.154729
ISSN: 1618-0631 (Electronic) 0344-0338 (Linking)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4501

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