Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population

Wed Jul 24 09:55:10 2024

(2018) Association of T/A polymorphism in miR-1302 binding site in CGA gene with male infertility in Isfahan population. Molecular Biology Reports. pp. 413-417. ISSN 0301-4851

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Infertility occurs in 10-15 of couples worldwide and close to half of it is caused by male factors. One of the genes that can affect male infertility is CGA. Polymorphisms in CGA gene may affect gene expression, therefore affecting male infertility by disrupting the regulation of this gene. One of the polymorphisms is the substitution of T with A in the miR-1302 binding site in the 3' untranslated region of the CGA gene. In this study, we explored this polymorphism in Isfahan population. In this case-control study, by the use of Tetra primer-ARMS-PCR technique, rs6631 has been investigated in 224 infertile men and 196 controls. Infertile men were recruited from Isfahan Fertility and Infertility Center. Analysis of genotype and allele frequencies indicated that the differences between case and control populations were significant for rs6631 because P = 0.00 which is above the threshold. We found a significant relationship between this polymorphism and male infertility. This study which performed for the first time in Iran suggests that polymorphism in CGA gene can affect male infertility. Also, this polymorphism has high heterozygosity, so it can be used for further studies in different populations.

Item Type: Article
Motovali-bashi, M.UNSPECIFIED
Keywords: Male infertility Polymorphism CGA gene Glycoprotein hormones glycoprotein hormones alpha micrornas target thyrotropin nucleotide molecules mechanism subunits receptor Biochemistry & Molecular Biology
Page Range: pp. 413-417
Journal or Publication Title: Molecular Biology Reports
Journal Index: ISI
Volume: 45
Number: 4
Identification Number:
ISSN: 0301-4851
Depositing User: مهندس مهدی شریفی

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