Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Application of accelerated failure time models for breast cancer patients' survival in Kurdistan Province of Iran

Fri May 24 11:13:19 2024

(2016) Application of accelerated failure time models for breast cancer patients' survival in Kurdistan Province of Iran. Journal of Cancer Research and Therapeutics. pp. 1184-1188. ISSN 0973-1482

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Context: Breast cancer is the most common cancer and the second common cause of cancer-induced mortalities in Iranian women. There has been a rapid development in hazard models and survival analysis in the last decade. Aims: The aim of this study was to evaluate the prognostic factors of overall survival (OS) in breast cancer patients using accelerated failure time models (AFM). Setting and Design: This was a retrospective-analytic cohort study. Subjects and Materials: About 313 women with a pathologically proven diagnosis of breast cancer who had been treated during a 7-year period (since January 2006 until March 2014) in Sanandaj City, Kurdistan Province of Iran were recruited. Statistical Analysis Used: Performance among AFT was assessed using the goodness of fit methods. Discrimination among the exponential, Weibull, generalized gamma, log-logistic, and log-normal distributions was done using Akaik information criteria and maximum likelihood. Results: The 5 years OS was 75 (95 Cl = 74.57-75.43). The main results in terms of survival were found for the different categories of the clinical stage covariate, tumor metastasis, and relapse of cancer. Survival time in breast cancer patients without tumor metastasis and relapse were 4, 2-fold longer than other patients with metastasis and relapse, respectively. Conclusion: One of the most important undermining prognostic factors in breast cancer is metastasis; hence, knowledge of the mechanisms of metastasis is necessary to prevent it so occurrence and treatment of metastatic breast cancer and ultimately extend the lifetime of patients.

Item Type: Article
Keywords: Accelerated failure time models breast cancer prognostic factors survival analysis cox hazard Oncology
Page Range: pp. 1184-1188
Journal or Publication Title: Journal of Cancer Research and Therapeutics
Journal Index: ISI
Volume: 12
Number: 3
Identification Number:
ISSN: 0973-1482
Depositing User: مهندس مهدی شریفی

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