Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19

Thu Apr 25 03:01:23 2024

(2023) Expression of TRIM56 gene in SARS-CoV-2 variants and its relationship with progression of COVID-19. Future Virology. p. 12. ISSN 1746-0794

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Tweetable abstract#Tavakoli et al. discovered that the TRIM56 gene, which plays a crucial role in the body's immune response to viruses, is likely associated with severe COVID-19 infections. Plain language summaryScientists looked at a protein called TRIM that helps fight viruses to see if a specific TRIM protein, TRIM56, was linked to how poorly people became with COVID-19. The study looked at the blood samples of 330 patients and found that COVID-19 patients had less TRIM56 than healthy people, especially those who were particularly ill. Aim: The present study aimed to determine a correlation between differential TRIM56 expression levels and severe infections of COVID-19 between the Alpha, Delta and Omicron BA.5 variants. Materials & methods: This study was performed on 330 COVID-19 patients, including 142 with severe and 188 with mild infections, as well as 160 healthy controls. The levels of TRIM56 gene expression were determined using a qPCR. Results: TRIM56 gene showed significantly lower mRNA expression in the severe and mild groups compared with healthy individuals. Our finding indicated the high and low reduction of TRIM56 mRNA expression in Delta and Omicron BA.5 variant, respectively. Conclusion: Further research is needed to characterize the impact of TRIM proteins on the severity of COVID-19.

Item Type: Article
Creators:
CreatorsEmail
Tavakoli, R.UNSPECIFIED
Rahimi, P.UNSPECIFIED
Hamidi-Fard, M.UNSPECIFIED
Eybpoosh, S.UNSPECIFIED
Doroud, D.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Aghasadeghi, M.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: C-reactive protein coronavirus disease 2019 mild infection SARS-CoV-2 severe infection tripartite motif containing 56 viral RNA load protein determinants association risk Virology
Divisions:
Page Range: p. 12
Journal or Publication Title: Future Virology
Journal Index: ISI
Identification Number: https://doi.org/10.2217/fvl-2022-0210
ISSN: 1746-0794
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4473

Actions (login required)

View Item View Item