Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of viruses in cancer development versus cancer therapy: An oncological perspective

Sun Apr 14 02:05:23 2024

(2023) The role of viruses in cancer development versus cancer therapy: An oncological perspective. Cancer Medicine. pp. 11127-11148. ISSN 2045-7634

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Abstract

Despite great medical advances, oncological research is still looking for novel therapeutic approaches due to the limitation of conventional therapeutic agents. Virotherapy is one of these new emerging therapeutic approaches that attract attention with their widespread applications. Virotherapy use lives oncolytic viruses or genetically engineered viruses that selectively infect the tumor cells, replicate, and disrupt the cancerous cells that also induce their anticancer activity by stimulating the host antitumor immune response. Moreover, viruses are widely used as target delivery vectors for specifically delivering different genes, therapeutic agents, and immune-stimulating agents. In addition to having antitumor activity by themselves in combination with conventional therapeutic agents like immune therapy and chemotherapy, Virotherapy agents also elicit promising outcomes. Therefore, in addition to their promising result in monotherapy use, virotherapy agents can also be used in combination with conventional cancer therapy, epigenetic modulators, and even microRNAs without any cross-resistance, which allows the patient not to be deprived of her routine medicine. Still, this combination therapy reduces the adverse effect of the conventional therapies. All together suggest that virotherapy agents as novel potential agents in the field of cancer therapy.

Item Type: Article
Creators:
CreatorsEmail
Javid, H.UNSPECIFIED
Mashhad, A. S.UNSPECIFIED
Yazdani, S.UNSPECIFIED
Oryani, M. A.UNSPECIFIED
Akbari, S.UNSPECIFIED
Rezagholinejad, N.UNSPECIFIED
Tajaldini, M.UNSPECIFIED
Karimi-Shahri, M.UNSPECIFIED
Keywords: carcinogen oncolytic viruses treatment virotherapy herpes-simplex-virus hepatitis-b-virus histone-deacetylase inhibitors epstein-barr-virus suberoylanilide hydroxamic acid squamous-cell carcinoma oncolytic adenovirus human-papillomavirus hepatocellular-carcinoma antitumor efficacy Oncology
Divisions:
Page Range: pp. 11127-11148
Journal or Publication Title: Cancer Medicine
Journal Index: ISI
Volume: 12
Number: 10
Identification Number: https://doi.org/10.1002/cam4.5694
ISSN: 2045-7634
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4472

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