Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Investigating the relationship between the number and activity of natural killer cells with increased cytomegalovirus and CMV disease after kidney transplantation

Tue Apr 16 09:31:57 2024

(2023) Investigating the relationship between the number and activity of natural killer cells with increased cytomegalovirus and CMV disease after kidney transplantation. Transplant Immunology. p. 5. ISSN 0966-3274

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Abstract

Background: Cytomegalovirus (CMV) infections caused by the cytomegalovirus are one of the most common problems in patients after kidney transplant. We examined the association of the relationship between the number and activity of natural killer cells with increased cytomegalovirus and its related disease after kidney transplantation.Material and methods: In this analytical study, 58 new transplant patients in the Labbafinejad Hospital, who did not have any evidence of CMV infection, were evaluated based on the number and percentage of CD56+/16+, CD56+/16-, and CD69+ Natural Killer (NK) cells.Results: The results of this study showed that CD16+ and CD56+ cells in the group of CMV Ag-positive patients are less than negative patients (p = 0.003) and the difference between the two groups are significant (p = 0.01). However, CD69+ cells did not differ significantly between the two groups (p = 0.1). Moreover, the absolute number of CD16+ and CD56+ cells declined significantly after infection with CMV unlike the CMV Ag - group(p = 0.003). Discussion: These results indicate that kidney transplant patients suffering from CMV infection after transplantation have a significantly reduced total number of NK cells. On the other hand, a slight decrease in the number of NK subgroups was observed with an increase in the peak serum levels of cyclosporine. As a consequence of these findings, it can be assumed that more dosage and a higher level of the drug will result in more severe immunosuppression and, consequently, increased susceptibility to CMV infections. Thus, taking the right dose of the drug would prevent viral infections and immune system from over-activation.

Item Type: Article
Creators:
CreatorsEmail
Asadzadeh, R.UNSPECIFIED
Nafar, M.UNSPECIFIED
Ahmadpoor, P.UNSPECIFIED
Samavat, S.UNSPECIFIED
Nikoueinejad, H.UNSPECIFIED
Hosseinzadeh, M.UNSPECIFIED
Mamizadeh, N.UNSPECIFIED
Hatami, S.UNSPECIFIED
Amirzargar, A.UNSPECIFIED
Keywords: Kidney transplantation NK-cell Cytomegalovirus cd69 expression cyclosporine-a t-lymphocytes infection inhibition activation receptor il-15 load Immunology Transplantation
Divisions:
Page Range: p. 5
Journal or Publication Title: Transplant Immunology
Journal Index: ISI
Volume: 80
Identification Number: https://doi.org/10.1016/j.trim.2023.101887
ISSN: 0966-3274
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4471

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