Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non-ICU wards in clinical randomized trials: A systematic review

Sat Apr 20 23:26:41 2024

(2023) Clinical efficacy of probiotics in prevention of infectious diseases among hospitalized patients in ICU and non-ICU wards in clinical randomized trials: A systematic review. Health Science Reports. p. 22.

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Abstract

Background and AimsThe present study aimed to review probiotics' clinical efficacy in preventing infectious diseases among hospitalized patients in ICU and non-ICU wards. MethodsA search of Medline, EMBASE, The Cochrane Library, Science Direct, Open Grey, and Google Scholar was conducted for eligible publications from 2002 to 2020 following the requirements outlined in the PRISMA guideline. The search strategy was based on the combination of the following terms: "probiotics," "prebiotics," "synbiotics," and "cross-infection." The logical operators "AND" (or the equivalent operator for the databases) and "OR" (e.g., probiotics OR prebiotics OR synbiotics) were used. ResultsThe results indicated that the probiotic consumption caused a significant reduction in antibiotic-associated diarrhea (AAD) and Clostridioides difficile infection (CDI) in 2/8 randomized clinical trials (RCTs) investigating AAD/CDI. Also, 5/12 clinical trials highlighted the considerable effects of probiotics on the reduction or prevention of ventilator associated pneumoniae (VAP), so the mean prevalence of VAP was lower in the probiotic group than in the placebo group. The total rate of nosocomial infections among preterm infants was nonsignificantly higher in the probiotic group compared to the control group. ConclusionThis systematic review shows that the administration of probiotics has moderate preventive or mitigating effects on the occurrence of VAP in ICU patients, CDI, AAD, and nosocomial infections among children. Consequently, applying antibiotics along with the proper probiotic species can be advantageous.

Item Type: Article
Creators:
CreatorsEmail
Darbandi, A.UNSPECIFIED
Banar, M.UNSPECIFIED
Koupaei, M.UNSPECIFIED
Afifirad, R.UNSPECIFIED
Asadollahi, P.UNSPECIFIED
Bafandeh, E.UNSPECIFIED
Rasooli, I.UNSPECIFIED
Emamie, A.UNSPECIFIED
Navidifar, T.UNSPECIFIED
Owlia, P.UNSPECIFIED
Keywords: antibiotic-associated diarrhea Clostridioides difficile infection nosocomial infections probiotic ventilator-associated pneumonia antibiotic-associated diarrhea ventilator-associated pneumonia lactobacillus-rhamnosus gg critically-ill patients reuteri dsm 17938 double-blind nosocomial diarrhea preterm infants saccharomyces-boulardii prophylactic probiotics Public, Environmental & Occupational Health General & Internal Medicine
Divisions:
Page Range: p. 22
Journal or Publication Title: Health Science Reports
Journal Index: ISI
Volume: 6
Number: 8
Identification Number: https://doi.org/10.1002/hsr2.1469
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4467

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