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Ilam University of Medical Sciences

A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity

Mon Feb 26 04:31:12 2024

(2023) A state-of-the-art review on the MicroRNAs roles in hematopoietic stem cell aging and longevity. Cell Communication and Signaling. p. 16.

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Abstract

Aging is a biological process determined through time-related cellular and functional impairments, leading to a decreased standard of living for the organism. Recently, there has been an unprecedented advance in the aging investigation, especially the detection that the rate of senescence is at least somewhat regulated via evolutionarily preserved genetic pathways and biological processes. Hematopoietic stem cells (HSCs) maintain blood generation over the whole lifetime of an organism. The senescence process influences many of the natural features of HSC, leading to a decline in their capabilities, independently of their microenvironment. New studies show that HSCs are sensitive to age-dependent stress and gradually lose their self-renewal and regeneration potential with senescence. MicroRNAs (miRNAs) are short, non-coding RNAs that post-transcriptionally inhibit translation or stimulate target mRNA cleavage of target transcripts via the sequence-particular connection. MiRNAs control various biological pathways and processes, such as senescence. Several miRNAs are differentially expressed in senescence, producing concern about their use as moderators of the senescence process. MiRNAs play an important role in the control of HSCs and can also modulate processes associated with tissue senescence in specific cell types. In this review, we display the contribution of age-dependent alterations, including DNA damage, epigenetic landscape, metabolism, and extrinsic factors, which affect HSCs function during aging. In addition, we investigate the particular miRNAs regulating HSCs senescence and age-associated diseases.

Item Type: Article
Creators:
CreatorsEmail
Ortiz, G. G. R.UNSPECIFIED
Mohammadi, Y.UNSPECIFIED
Nazari, A.UNSPECIFIED
Ataeinaeini, M.UNSPECIFIED
Kazemi, P.UNSPECIFIED
Yasamineh, S.UNSPECIFIED
Al-Naqeeb, B. Z. T.UNSPECIFIED
Zaidan, H. K.UNSPECIFIED
Gholizadeh, O.UNSPECIFIED
Keywords: MicroRNA Hematopoietic stem cell Aging Anti-aging DNA-damage repair human bone-marrow down-regulation epigenetic regulation progenitor cells age cancer maintenance mechanisms expression Cell Biology
Divisions:
Page Range: p. 16
Journal or Publication Title: Cell Communication and Signaling
Journal Index: ISI
Volume: 21
Number: 1
Identification Number: https://doi.org/10.1186/s12964-023-01117-0
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4465

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