(2022) The role of heat shock proteins in metastatic colorectal cancer: A review. Journal of Cellular Biochemistry. pp. 1704-1735. ISSN 0730-2312
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Abstract
Heat shock proteins (HSPs) are a large molecular chaperone family classified by their molecular weights, including HSP27, HSP40, HSP60, HSP70, HSP90, and HSP110. HSPs are likely to have antiapoptotic properties and participate actively in various processes such as tumor cell proliferation, invasion, metastases, and death. In this review, we discuss comprehensively the functions of HSPs associated with the progression of colorectal cancer (CRC) and metastasis and resistance to cancer therapy. Taken together, HSPs have numerous clinical applications as biomarkers for cancer diagnosis and prognosis and potential therapeutic targets for CRC and its related metastases.
| Item Type: | Article | ||||||||||||
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| Keywords: | colorectal cancer (CRC) heat shock proteins (HSPs) metastatic colorectal cancer alpha-b-crystallin epithelial-mesenchymal transition endothelial growth-factor colon-cancer beta-catenin tumor-suppressor therapeutic target breast-cancer cell-cycle heat-shock-protein-60 hsp60 Biochemistry & Molecular Biology Cell Biology | ||||||||||||
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| Page Range: | pp. 1704-1735 | ||||||||||||
| Journal or Publication Title: | Journal of Cellular Biochemistry | ||||||||||||
| Journal Index: | ISI | ||||||||||||
| Volume: | 123 | ||||||||||||
| Number: | 11 | ||||||||||||
| Identification Number: | https://doi.org/10.1002/jcb.30326 | ||||||||||||
| ISSN: | 0730-2312 | ||||||||||||
| Depositing User: | مهندس مهدی شریفی | ||||||||||||
| URI: | http://eprints.medilam.ac.ir/id/eprint/4460 |
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