Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Serum C-Reactive Protein in Children with Liver Disease and Ascites

Thu Apr 18 00:46:36 2024

(2016) Serum C-Reactive Protein in Children with Liver Disease and Ascites. Hepatitis Monthly. p. 7. ISSN 1735-143X

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Background: The diagnosis of peritonitis as a complication of cirrhosis is an important clinical problem. Objectives: The aim of this study was to evaluate serum C-reactive protein levels as a diagnostic factor for spontaneous bacterial peritonitis (SBP) in child patients with liver disease. Methods: In this study, 150 children diagnosed with liver disease and ascites upon admission to Nemazee Teaching Hospital (Shiraz, Iran) were examined. Patients were divided into spontaneous bacterial peritonitis and sterile ascetic fluid groups according to the PMN count >= 250/mm(3) in the ascetic fluids. Routine laboratory tests were conducted and quantitative C-reactive protein (CRP) levels were measured for all of the patients. Accuracy, sensitivity, and specificity of CRP was evaluated for diagnosis of SBP. Results: Of 150 cirrhotic patients, 109 patients presented without SBP (52.29 male, mean age: 5.02 +/- 4.49 years) and 41 patients presented with SBP (51.21 male, mean age: 4.71 years). Cell counts, protein levels, albumin levels, and lactate dehydrogenize (LDH) levels of the ascetic fluid and serum samples in the SBP group were higher than the rates for those without SBP (P < 0.05(. The mean +/- SD of CRP in the SBP group (36.89 +/- 23.43) increased significantly compared to the rate among those without SBP (21.59 +/- 15.43, P = 0.001). The percentages for sensitivity and specificity of CRP, the diagnosis of SBP based on the PMN count >= 250/mm(3), and cultured ascites were 69.23, 90.25, 88.43, and 84.32, respectively. The areas under the curve of CRP for SBP based on the PMN count >= 250/mm(3) and cultured ascites was 0.94 (CI 95: 0.90 to 0.96) and 0.85 (CI 95: 0.84 to 0.92), respectively (P < 0.001). Conclusions: Our study showed that CRP is a marker with high sensitivity and specificity for the diagnosis of SBP in cirrhotic children.

Item Type: Article
Geramizadeh, B.UNSPECIFIED
Javaherizadeh, H.UNSPECIFIED
Keywords: Cirrhosis C-Reactive Protein Peritonitis spontaneous bacterial peritonitis reagent strips severe sepsis escherichia-coli rapid diagnosis cirrhosis procalcitonin infections indicator cytokine Gastroenterology & Hepatology
Page Range: p. 7
Journal or Publication Title: Hepatitis Monthly
Journal Index: ISI
Volume: 16
Number: 8
Identification Number:
ISSN: 1735-143X
Depositing User: مهندس مهدی شریفی

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