Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats

Mon Mar 4 04:58:18 2024

(2023) Effects of choline supplementation in mothers with hypothyroidism on the brain-derived neurotrophic factor gene expression changes in pre-pubertal offspring rats. Molecular Biology Reports. pp. 2351-2356. ISSN 0301-4851

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Abstract

Background Thyroid hormones play a vital function in the maturation in the course of mind development. Regarding the well-known effects of choline on brain-derived neurotrophic factor (BDNF), the study examined the effects of choline on hippocampal BDNF gene expression in maternal hypothyroidism rats. Methods and results To induce the hypothyroidism, 6-propyl-2-thiouracil was introduced to the ingesting water from the sixth day of gestation to twenty-first postnatal day (PND). Choline-treatment started twice a day on the first day of gestation until PND 21. On PND28, pups were sacrificed. The expression of BDNF gene was evaluated after the hippocampus was harvested. Our results demonstrated that both male and female pre-pubertal offspring rats' BDNF gene expression was decreased by developmental hypothyroidism. Choline increases the ratio of relative gene expression of BDNF in the hippocampus of males and females in the control/hypothyroidism group, especially in males. Conclusions It can be concluded that maternal choline supplementation on the first day of gestation until PND 21 improves brain development and cognitive function in pre-pubertal offspring rats regarding control/hypothyroidism groups.

Item Type: Article
Creators:
CreatorsEmail
Sheikhi, S.UNSPECIFIED
Derafshpour, L.UNSPECIFIED
Aghazadeh, R.UNSPECIFIED
Sayyadi, H.UNSPECIFIED
Saboory, E.UNSPECIFIED
Bagheri, M.UNSPECIFIED
Keywords: Choline supplementation Hypothyroidism BDNF Gene expression Rat blood choline bdnf polymorphisms pregnancy hormones sex Biochemistry & Molecular Biology
Divisions:
Page Range: pp. 2351-2356
Journal or Publication Title: Molecular Biology Reports
Journal Index: ISI
Volume: 50
Number: 3
Identification Number: https://doi.org/10.1007/s11033-022-08014-8
ISSN: 0301-4851
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4454

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