Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Aspirin-Exacerbated Respiratory Disease Polymorphisms; a review study

Wed Jun 19 20:12:19 2024

(2023) Aspirin-Exacerbated Respiratory Disease Polymorphisms; a review study. Gene. p. 23. ISSN 0378-1119

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Abstract

Aspirin exacerbated respiratory disease (AERD) is a condition caused by increased bronchoconstriction in people with asthma after taking aspirin or another NSAID. Molecular analysis of the human genome has opened up new perspectives on human polymorphisms and disease. This study was conducted to identify the genetic factors that influence this disease due to its unknown genetic factors. We evaluated research studies, letters, comments, editorials, eBooks, and reviews. PubMed/MEDLINE, Web of Sciences, Cochrane Library, and Scopus were searched for information. We used the keywords polymorphisms, aspirin-exacerbated respiratory disease, asthma, allergy as search terms. This study included 38 studies. AERD complications were associated with polymorphisms in ALOX15, EP2, ADRB2, SLC6A12, CCR3, CRTH2, CysLTs, DPCR1, DPP10, FPR2, HSP70, IL8, IL1B, IL5RA, IL-13, IL17RA, ILVBL, TBXA2R, TLR3, HLA-DRB and HLA-DQ, HLA-DR7, HLA-DP. AERD was associated with heterogeneity in gene polymorphisms, making it difficult to pinpoint specific gene changes. Therefore, diagnosing and treating AERD may be facilitated by examining common variants involving the disease.

Item Type: Article
Creators:
CreatorsEmail
Fathollahpour, A.UNSPECIFIED
Abyaneh, F. A.UNSPECIFIED
Darabi, B.UNSPECIFIED
Ebrahimi, M.UNSPECIFIED
Kooti, W.UNSPECIFIED
Kalmarzi, R. N.UNSPECIFIED
Keywords: Polymorphisms Aspirin-Exacerbated Respiratory Disease Asthma Allergy single nucleotide polymorphisms cysteinyl leukotriene receptors intolerant asthma association analysis gene polymorphisms japanese patients prostaglandin e-2 chronic rhinosinusitis allergic rhinitis c-4 synthase Genetics & Heredity
Divisions:
Page Range: p. 23
Journal or Publication Title: Gene
Journal Index: ISI
Volume: 870
Identification Number: https://doi.org/10.1016/j.gene.2023.147326
ISSN: 0378-1119
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4438

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