Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Long non coding RNAs reveal important pathways in childhood asthma: a future perspective

Mon Mar 4 11:40:13 2024

(2023) Long non coding RNAs reveal important pathways in childhood asthma: a future perspective. Journal of Molecular Histology. pp. 257-269. ISSN 1567-2379

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Abstract

Asthma is a long-term inflammatory disease of the airways of the lungs refers changes that occur in conjunction with, or as a result of, chronic airway inflammation. Airway remodeling the subsequent of inflammation constitutes cellular and extracellular matrix changes in the wall airways, epithelial-to-mesenchymal-transition and airway smooth muscle cell proliferation. Diseases often begin in childhood and despite extensive research, causative pathogenic mechanisms still remain unclear. Transcriptome analysis of childhood asthma reveals distinct gene expression profiles of Long noncoding RNAs which have been reported to play a central regulatory role in various aspects of pathogenesis, clinical course and treatment of asthma. We briefly review current understanding of lnc-RNA dysregulation in children with asthma, focusing on their complex role in the inflammation, cell proliferation and remodeling of airway to guide future researches. We found that the lnc-RNAs increases activity of several oncogenes such c-Myc, Akt, and ERK and various signaling pathways such as MAPK (PI3K, Ras, JNK and p38), NF-& kappa;B and Wnt and crosstalk between these pathways by TGF & beta;, & beta;-catenin, ERK and SKP2. Moreover, two different signal transduction pathways, Wnt and Notch1, can be activated by two lnc-RNAs through sponging the same miRNA for exacerbation cell proliferation.

Item Type: Article
Creators:
CreatorsEmail
Goodarzi, V.UNSPECIFIED
Nouri, S.UNSPECIFIED
Nassaj, Z. S.UNSPECIFIED
Bighash, M.UNSPECIFIED
Abbasian, S.UNSPECIFIED
Hagh, R. A.UNSPECIFIED
Keywords: Long non-coding RNAs Asthma Pathogenesis factor-kappa-b monocyte-chemoattractant protein-1 airway smooth-muscle growth-factor expression cell lung-cancer gene-expression matrix metalloproteinase-16 transcription factor lncrna kcnq1ot1 down-regulation Cell Biology
Divisions:
Page Range: pp. 257-269
Journal or Publication Title: Journal of Molecular Histology
Journal Index: ISI
Volume: 54
Number: 4
Identification Number: https://doi.org/10.1007/s10735-023-10131-y
ISSN: 1567-2379
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4435

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