Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Synthesis of Fe3O4 nanoparticles encapsulated with orange pectin for the treatment of gastrointestinal cancers

Tue Apr 16 09:18:34 2024

(2022) Synthesis of Fe3O4 nanoparticles encapsulated with orange pectin for the treatment of gastrointestinal cancers. Materials Express. pp. 1455-1464. ISSN 2158-5849

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Abstract

The current work reports a unique bio-inspired synthesis of orange derived pectin modified magnetite IP: 5 10 31 211 On Wed 29 Mar 2023 13 15:49 nanoparticles (Fe3O4 NPs). Pectinis a naurally ocurring bopolymer containing plethora of polar organo-Copy ght: American Scientific Publishers functions which are exploited in the toxic reagnt fe modificaion of biocompatible magnetic NPs and also Delivered by Ingenta towards the stabilization of NPs by preventing them from agglomeration. The physicochemical properties of the as-prepared bio-nanocomposite (Fe3O4@Pectin) was analytically investigated through SEM, EDX, TEM, VSM and XRD. The anti-gastrointestinal system cancers and cytotoxic potentials of synthesized NPs against cancer cell lines were assessed. The anti-gastrointestinal system cancers potentials of the NPscould signifi-cantly remove (HT-29, HCT 116, Ramos.2G6.4C10, HCT-8 (Colorectal cancer)), (Capan-2, AsPC-1, CFPAC-1, HPAF-II (Pancreatic cancer)), (GC1436, GC1401, AGS, and GC1415 (Gastric cancer)) cell lines by MTT assay. The corresponding IC50 were found as 13, 8, 16, 15, 11, 12, 15, 15, 23, 36, 30, and 23 mu g/mL against HT-29, HCT 116, Ramos.2G6.4C10, HCT-8, Capan-2, AsPC-1, CFPAC-1, HPAF-II, GC1436, GC1401, AGS, and GC1415 cancer cell lines. Furthermore, the antioxidant capacity of Fe3O4@Pectin NPswas determined by DPPH method which displayeda significant activity as per IC50 value. It is believed that the antioxidant effects play a significant role in the considerable anti-colorectal, pancreatic and gastric cancerseffects.

Item Type: Article
Creators:
CreatorsEmail
Zong, H. T.UNSPECIFIED
Zhang, S. Y.UNSPECIFIED
Zangeneh, M. M.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Saremi, S. G.UNSPECIFIED
Kamangar, S. A.UNSPECIFIED
Pirhayati, M.UNSPECIFIED
Keywords: Nanocomposite Magnetic Pectin Cytotoxicity Anti-Gastrointestinal System Cancers up-conversion nanoparticles iron-oxide nanoparticles photodynamic therapy tio2 nanoparticles green synthesis radiation antibacterial hyperthermia antioxidant delivery Science & Technology - Other Topics Materials Science
Divisions:
Page Range: pp. 1455-1464
Journal or Publication Title: Materials Express
Journal Index: ISI
Volume: 12
Number: 12
Identification Number: https://doi.org/10.1166/mex.2022.2314
ISSN: 2158-5849
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4433

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