Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword

Wed Feb 28 12:32:29 2024

(2022) The effect of COVID-19 derived cytokine storm on cancer cells progression: double-edged sword. Molecular Biology Reports. pp. 605-615. ISSN 0301-4851

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Abstract

Objective Severe acute respiratory syndrome coronavirus 2 (SARS-COV2) was first detected in Wuhan, China in December, 2019. The emerging virus causes a respiratory illness, that can trigger a cytokine storm in the body. Method Cytokine storm in patient's body is associated with severe forms of disease. It is one of the main complications of coronavirus disease-2019 (COVID-19), in which immune cells play a major role. Studies have shown immune cells in the tumor environment can be effective to induce resistance to chemotherapy in cancer patients. Result Therefore, considering the role of immune cells to induce cytokine storm in COVID-19 patients, and their role to cause resistance to chemotherapy, they are effective on disease progression and creation of severe form of disease. Conclusion By examining the signaling pathways and inducing resistance to chemotherapy in tumor cells and the cells affect them, it is possible to prevent the occurrence of severe forms of the disease in cancer patients with COVID-19; it is applicable using target therapy and other subsequent treatment strategies.

Item Type: Article
Creators:
CreatorsEmail
Heydarian, M.UNSPECIFIED
Mohammadtaghizadeh, M.UNSPECIFIED
Shojaei, M.UNSPECIFIED
Babazadeh, M.UNSPECIFIED
Abbasian, S.UNSPECIFIED
Amrovani, M.UNSPECIFIED
Keywords: Cytokine storm Chemotherapy resistance Pathogenesis COVID-19 epithelial-mesenchymal transition growth-factor-beta colorectal-cancer activation emt chemoresistance pathway phosphorylation inflammation metastasis Biochemistry & Molecular Biology
Divisions:
Page Range: pp. 605-615
Journal or Publication Title: Molecular Biology Reports
Journal Index: ISI
Volume: 49
Number: 1
Identification Number: https://doi.org/10.1007/s11033-021-06800-4
ISSN: 0301-4851
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4416

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