Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Green synthesis of gold nanoparticles using potato starch as a phytochemical template, green reductant and stabilizing agent and investigating its cytotoxicity, antioxidant and anti-ovarian cancer effects

Mon Apr 22 22:24:07 2024

(2023) Green synthesis of gold nanoparticles using potato starch as a phytochemical template, green reductant and stabilizing agent and investigating its cytotoxicity, antioxidant and anti-ovarian cancer effects. Inorganic Chemistry Communications. p. 8. ISSN 1387-7003

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Abstract

Herein we have demonstrated a sustainable pathway for the Au nanoparticles synthesis using potato starch as a phytochemical template, green reductant and stabilizing agent. The reaction was initiated by ultrasound irradiation as a non-conventional source of energy. As-synthesized nanocomposite material (Starch/Au NPs) physicochemical characteristics was determined over several analytical techniques like TEM, UV-Vis, SEM, XRD and EDX. The in vitro cytotoxic and anti-ovarian potentials of biologically synthesized Starch/Au nanocomposite were assessed against OVCAR-3 and OVCAR-4 cancer cells. The anti-ovarian cancer activities of the Starch/Au nanocomposite were validated by the significant diminishing of OVCAR-3 and OVCAR-4 cancer cells. The IC50 of the Starch/Au nanocomposite were found as 285 and 189 & mu;g/mL respectively against the said cell lines. The outstanding results of this current research definitely could lead the biologically synthesized Starch/Au nancomposite as a potential adjuvant chemopreventive and chemotherapeutic agent to cure the ovarian cancer. The material also exhibited significant antioxidant properties. However, it necessitates in vivo animal studies to ascertain further evidences as anti-ovarian cancer agents.

Item Type: Article
Creators:
CreatorsEmail
Li, J.UNSPECIFIED
Feizipour, S.UNSPECIFIED
Delirezh, N.UNSPECIFIED
Sheikhzadeh, S.UNSPECIFIED
Hobbenaghi, R.UNSPECIFIED
Amraii, S. A.UNSPECIFIED
Khorasani, F.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Joshani, Z.UNSPECIFIED
Kamangar, S. A.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Saremi, S. G.UNSPECIFIED
Almasi, M.UNSPECIFIED
Keywords: Au nanoparticles Starch Chemotherapeutic agent Anti-ovarian carcinoma ultrasound-assisted synthesis targeted drug-delivery pd nps recyclable nanocatalyst aqueous extract colloidal gold tumor size nanotechnology biosynthesis Chemistry
Divisions:
Page Range: p. 8
Journal or Publication Title: Inorganic Chemistry Communications
Journal Index: ISI
Volume: 155
Identification Number: https://doi.org/10.1016/j.inoche.2023.111002
ISSN: 1387-7003
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4409

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