Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants

Thu Nov 7 22:47:07 2024

(2023) The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants. Human Genomics. p. 11. ISSN 1473-9542

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

BackgroundClinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outcomes could be influenced by genetic polymorphisms in angiotensin I-converting enzyme (ACE1) and ACE2. This study aims to examine three polymorphisms (rs1978124, rs2285666, and rs2074192) on the ACE2 gene and ACE1 rs1799752 (I/D) in patients who have coronavirus disease 2019 (COVID-19) with various SARS-CoV-2 variants.MethodsBased on polymerase chain reaction-based genotyping, four polymorphisms in the ACE1 and ACE2 genes have been identified in 2023 deceased patients and 2307 recovered patients.ResultsThe ACE2 rs2074192 TT genotype was associated with the COVID-19 mortality in all three variants, whereas the CT genotype was associated with the Omicron BA.5 and Delta variants. ACE2 rs1978124 TC genotypes were related to COVID-19 mortality in the Omicron BA.5 and Alpha variants, but TT genotypes were related to COVID-19 mortality in the Delta variant. It was found that ACE2 rs2285666 CC genotypes were associated with COVID-19 mortality in Delta and Alpha variants, and CT genotypes in Delta variants. There was an association between ACE1 rs1799752 DD and ID genotypes in the Delta variant and COVID-19 mortality, whereas there was no association in the Alpha or Omicron BA.5 variants. In all variants of SARS-CoV-2, CDCT and TDCT haplotypes were more common. In Omicron BA.5 and Delta, CDCC and TDCC haplotypes were linked with COVID-19 mortality. In addition to COVID-19 mortality, the CICT, TICT, and TICC were significantly correlated.ConclusionThe ACE1/ACE2 polymorphisms had an impact on COVID-19 infection, and these polymorphisms had different effects in various SARS-CoV-2 variants. To confirm these results, however, more research needs to be conducted.

Item Type: Article
Creators:
CreatorsEmail
Sheikhian, F.UNSPECIFIED
Mofrad, S. S.UNSPECIFIED
Tarashi, S.UNSPECIFIED
Jajin, M. G.UNSPECIFIED
Sakhaee, F.UNSPECIFIED
Ahmadi, I.UNSPECIFIED
Anvari, E.UNSPECIFIED
Sheikhpour, M.UNSPECIFIED
Fateh, A.UNSPECIFIED
Keywords: SARS-CoV-2 variants COVID-19 ACE2 polymorphisms ACE1 rs1799752 gene severity receptor hypertension association population infection i/d Genetics & Heredity
Divisions:
Page Range: p. 11
Journal or Publication Title: Human Genomics
Journal Index: ISI
Volume: 17
Number: 1
Identification Number: https://doi.org/10.1186/s40246-023-00501-8
ISSN: 1473-9542
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4396

Actions (login required)

View Item View Item