Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The effect of metformin administration on cancer-specific survival, overall survival, progression-free survival, and disease progression in renal cell carcinoma patients; a systematic review and meta-analysis

Fri Apr 19 13:58:03 2024

(2023) The effect of metformin administration on cancer-specific survival, overall survival, progression-free survival, and disease progression in renal cell carcinoma patients; a systematic review and meta-analysis. Journal of Renal Injury Prevention. p. 6. ISSN 2345-2781

Full text not available from this repository.

Official URL: http://apps.webofknowledge.com/InboundService.do?F...

Abstract

Introduction: The increase in the incidence of renal cell carcinoma (RCC) has been reported worldwide. The anti-cancer impacts of metformin on the various types of cancer have been observed in clinical studies. Therefore, this study aims to survey the effect of metformin use on RCC patients using systematic review and meta-analysis methods. Materials and Methods: In this research, Cochrane, Web of Science, PubMed, Scopus databases, and Google Scholar web browser were searched using standard keywords. Data were analyzed with STATA 14 software. The significance level of tests P < 0.05 was considered. Results: The improvement in the progression-free survival (PFS) (HR: 0.72 (95 CI: 0.54, 0.94), P= 0.169, I2= 37.8) and cancer-specific survival (CSS) (HR: 0.36 (95 CI: 0.18, 0.75), P= 0.339, I2 = 7.5) was observed in eight studies with 10404 patients affected by RCC. However, no significant statistical effect was observed on the improvement in the disease progression (OR: 1.10 (95 CI: 0.85, 1.42), P= 0.326, I2 = 0) and cancer overall survival (OS) (HR: 0.72 (95 CI: 0.51, 1.01), P= 0.153, I2= 43.1). Conclusion: This study showed metformin administration improved CSS and PFS in RCC patients. More studies are warranted on the effect of metformin on the improvement in disease progression and OS of cancer. Registration: This study has been compiled based on the PRISMA checklist, and its protocol was registered on the PROSPERO website (ID= CRD42022369108; https://www.crd.york. ac.uk/prospero/displayrecord.php?ID=CRD42022369108).

Item Type: Article
Creators:
CreatorsEmail
Nourmohammadi, H.UNSPECIFIED
Jamshidbeigi, T.UNSPECIFIED
Abdan, Z.UNSPECIFIED
Sarokhani, D.UNSPECIFIED
Fakhri, M.UNSPECIFIED
Alaienezhad, S.UNSPECIFIED
Keywords: Overall survival Cancer-specific survival Disease progression Metformin Renal cell carcinoma Progression-free survival prostate-cancer risk impact epidemiology statement outcomes Urology & Nephrology
Divisions:
Page Range: p. 6
Journal or Publication Title: Journal of Renal Injury Prevention
Journal Index: ISI
Identification Number: https://doi.org/10.34172/jrip.2023.32158
ISSN: 2345-2781
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4391

Actions (login required)

View Item View Item