Repository of Research and Investigative Information

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Ilam University of Medical Sciences

The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis

Sat Apr 20 02:38:34 2024

(2023) The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis. Bmc Infectious Diseases. p. 30.

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Abstract

BackgroundHelicobacter pylori is a gastrointestinal pathogen that infects around half of the world's population. H. pylori infection is the most severe known risk factor for gastric cancer (GC), which is the second highest cause of cancer-related deaths globally. We conducted a systematic review and meta-analysis to assess the global prevalence of GC in H. pylori-infected individuals.MethodsWe performed a systematic search of the PubMed, Web of Science, and Embase databases for studies of the prevalence of GC in H. pylori-infected individuals published from 1 January 2011 to 20 April 2021. Metaprop package were used to calculate the pooled prevalence with 95 confidence interval. Random-effects model was applied to estimate the pooled prevalence. We also quantified it with the I-2 index. Based on the Higgins classification approach, I-2 values above 0.7 were determined as high heterogeneity.ResultsAmong 17,438 reports screened, we assessed 1053 full-text articles for eligibility; 149 were included in the final analysis, comprising data from 32 countries. The highest and lowest prevalence was observed in America (pooled prevalence: 18.06; 95 CI: 16.48 - 19.63; I-2: 98.84) and Africa (pooled prevalence: 9.52; 95 CI: 5.92 - 13.12; I-2: 88.39). Among individual countries, Japan had the highest pooled prevalence of GC in H. pylori positive patients (Prevalence: 90.90:95 CI: 83.61-95.14), whereas Sweden had the lowest prevalence (Prevalence: 0.07; 95 CI: 0.06-0.09). The highest and lowest prevalence was observed in prospective case series (pooled prevalence: 23.13; 95 CI: 20.41 - 25.85; I2: 97.70) and retrospective cohort (pooled prevalence: 1.17; 95 CI: 0.55 - 1.78; I 2: 0.10).ConclusionsH. pylori infection in GC patients varied between regions in this systematic review and meta-analysis. We observed that large amounts of GCs in developed countries are associated with H. pylori. Using these data, regional initiatives can be taken to prevent and eradicate H. pylori worldwide, thus reducing its complications.

Item Type: Article
Creators:
CreatorsEmail
Shirani, M.UNSPECIFIED
Pakzad, R.UNSPECIFIED
Haddadi, M. H.UNSPECIFIED
Akrami, S.UNSPECIFIED
Asadi, A.UNSPECIFIED
Kazemian, H.UNSPECIFIED
Moradi, M.UNSPECIFIED
Kaviar, V. H.UNSPECIFIED
Zomorodi, A. R.UNSPECIFIED
Khoshnood, S.UNSPECIFIED
Shafieian, M.UNSPECIFIED
Tavasolian, R.UNSPECIFIED
Heidary, M.UNSPECIFIED
Saki, M.UNSPECIFIED
Keywords: Infection Prevalence Gastric cancer Helicobacter pylori Systematic review Meta-analysis peptic-ulcer disease dyspeptic patients follow-up high-risk antibiotic-resistance virulence factors serum pepsinogen iranian patients potential role tnf-alpha Infectious Diseases
Divisions:
Page Range: p. 30
Journal or Publication Title: Bmc Infectious Diseases
Journal Index: ISI
Volume: 23
Number: 1
Identification Number: https://doi.org/10.1186/s12879-023-08504-5
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4385

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