Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

COVID-19-associated opportunistic infections: a snapshot on the current reports

Wed May 29 13:15:30 2024

(2022) COVID-19-associated opportunistic infections: a snapshot on the current reports. Clinical and Experimental Medicine. pp. 327-346. ISSN 1591-8890

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Treatment of the novel Coronavirus Disease 2019 (COVID-19) remains a complicated challenge, especially among patients with severe disease. In recent studies, immunosuppressive therapy has shown promising results for control of the cytokine storm syndrome (CSS) in severe cases of COVID-19. However, it is well documented that immunosuppressive agents (e.g., corticosteroids and cytokine blockers) increase the risk of opportunistic infections. On the other hand, several opportunistic infections were reported in COVID-19 patients, including Aspergillus spp., Candida spp., Cryptococcus neoformans, Pneumocystis jiroveci (carinii), mucormycosis, Cytomegalovirus (CMV), Herpes simplex virus (HSV), Strongyloides stercoralis, Mycobacterium tuberculosis, and Toxoplasma gondii. This review is a snapshot about the main opportunistic infections that reported among COVID-19 patients. As such, we summarized information about the main immunosuppressive agents that were used in recent clinical trials for COVID-19 patients and the risk of opportunistic infections following these treatments. We also discussed about the main challenges regarding diagnosis and treatment of COVID-19-associated opportunistic infections (CAOIs).

Item Type: Article
Keywords: COVID-19 SARS-CoV-2 Opportunistic infection Cytokine storm syndrome Immunosuppressive therapy Aspergillosis Candidiasis Mucormycosis Cryptococcosis Pneumocystis jirovecii pneumonia Tuberculosis Cytomegalovirus Herpes simplex virus Toxoplasmosis Strongyloidiasis Helminth infections allergic bronchopulmonary aspergillosis pneumocystis-jirovecii pneumonia strongyloides-stercoralis hyperinfection corticosteroid-treated patients renal-transplant recipients rheumatoid-arthritis infliximab therapy invasive aspergillosis pulmonary mucormycosis coronavirus disease Research & Experimental Medicine
Page Range: pp. 327-346
Journal or Publication Title: Clinical and Experimental Medicine
Journal Index: ISI
Volume: 22
Number: 3
Identification Number:
ISSN: 1591-8890
Depositing User: مهندس مهدی شریفی

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