Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders

Sat Jun 22 19:07:04 2024

(2023) Effect of alcohol consumption on breast cancer: probabilistic bias analysis for adjustment of exposure misclassification bias and confounders. Bmc Medical Research Methodology. p. 13.

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Abstract

PurposeThis study was conducted to evaluate the effect of alcohol consumption on breast cancer, adjusting for alcohol consumption misclassification bias and confounders.MethodsThis was a case-control study of 932 women with breast cancer and 1000 healthy control. Using probabilistic bias analysis method, the association between alcohol consumption and breast cancer was adjusted for the misclassification bias of alcohol consumption as well as a minimally sufficient set of adjustment of confounders derived from a causal directed acyclic graph. Population attributable fraction was estimated using the Miettinen's Formula.ResultsBased on the conventional logistic regression model, the odds ratio estimate between alcohol consumption and breast cancer was 1.05 (95 CI: 0.57, 1.91). However, the adjusted estimates of odds ratio based on the probabilistic bias analysis ranged from 1.82 to 2.29 for non-differential and from 1.93 to 5.67 for differential misclassification. Population attributable fraction ranged from 1.51 to 2.57 using non-differential bias analysis and 1.54-3.56 based on differential bias analysis.ConclusionA marked measurement error was in self-reported alcohol consumption so after correcting misclassification bias, no evidence against independence between alcohol consumption and breast cancer changed to a substantial positive association.

Item Type: Article
Creators:
CreatorsEmail
Pakzad, R.UNSPECIFIED
Nedjat, S.UNSPECIFIED
Salehiniya, H.UNSPECIFIED
Mansournia, N.UNSPECIFIED
Etminan, M.UNSPECIFIED
Nazemipour, M.UNSPECIFIED
Pakzad, I.UNSPECIFIED
Mansournia, M. A.UNSPECIFIED
Keywords: Probabilistic bias analysis Alcohol consumption Breast cancer Monte-Carlo sensitivity analysis Population attributable fraction sensitivity-analysis attributable risk causal diagrams cigarette-smoking life-style drinking metaanalysis association population women Health Care Sciences & Services
Divisions:
Page Range: p. 13
Journal or Publication Title: Bmc Medical Research Methodology
Journal Index: ISI
Volume: 23
Number: 1
Identification Number: https://doi.org/10.1186/s12874-023-01978-6
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4378

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