Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review

Mon Jun 24 04:48:42 2024

(2023) Occult hepatitis B in Iranian blood donors, an overview of the challenges: A narrative review. Health Science Reports. p. 8.

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BackgroundOccult hepatitis B infection (OBI) is a transfusion-transmitted infection. Although, screening the hepatitis B virus among blood donors can play an important role in increasing the health of blood products, OBI screening in blood transfusion centers is still a challenge. This review study aimed to appraise the challenges of OBI screening and its associated do's and don'ts in blood transfusion centers. MethodsIn this review study, a search was conducted on the electronic databases of PubMed, Web of Science, Scopus, Ovid, Irandoc, and Magiran from January 1996 to December 2020. Also, cross-sectional studies that determined the prevalence of OBI or anti-HBc were included in the study. In addition, studies with incomplete data on the prevalence of OBI were excluded. ResultsThe prevalence of OBI varies among Iranian blood donors. The rates reported by blood transfusion centers of Mashhad, Ahvaz, and Tehran were 0, and Isfahan, Shiraz, and Kerman were 0.9, 0.08, and 2.36, respectively. In areas with high prevalence of hepatitis B virus, OBI screening only by anti-HBc test led to the exemption of blood donors from donating blood. Avoiding OBI screening also effected the risk of virus transmission to blood recipients. Plasma products had a higher risk (85) of virus transmission. ConclusionsDetermining an appropriate screening strategy based on prevalence status, the cost-effectiveness of screening tests, and the policies of each blood transfusion center is essential.

Item Type: Article
Keywords: blood donors blood transfusion hepatitis infection prevalence virus infection anti-hbc transfusion medicine clinical impact DNA prevalence components risk epidemiology individuals Public, Environmental & Occupational Health General & Internal Medicine
Page Range: p. 8
Journal or Publication Title: Health Science Reports
Journal Index: ISI
Volume: 6
Number: 8
Identification Number:
Depositing User: مهندس مهدی شریفی

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