Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori-related diseases

Wed Jun 19 00:51:50 2024

(2022) Benzimidazole derivatives: A versatile scaffold for drug development against Helicobacter pylori-related diseases. Fundamental & Clinical Pharmacology. pp. 930-943. ISSN 0767-3981

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Helicobacter pylori (H. pylori) is a microaerophilic gastric pathogen and a major contributor to chronic atrophic gastritis, peptic ulcer, and gastric malignancies. The increasing prevalence of H. pylori infection and its related diseases, such as gastric cancer (GC), motivates medicinal chemists to seek for more effective multi-targeting drugs to prevent and treat H. pylori-related clinical complications. Benzimidazole, a hetero-aromatic bicyclic ring compound, has claimed a prominent role in medicinal chemistry owing to its broad range of biological activities, including antibacterial, antiviral, antidiabetic, and anticancer activities. Studies highlight the promising therapeutic potential of benzimidazole derivatives in the treatment of H. pylori-related clinical complications such as gastric infection, gastritis, peptic ulcer, and GC. Accordingly, we here aimed to scrutinize the role of active molecules of benzimidazole derivatives as potential antibacterial, anti-urease, anti-inflammatory, anti-ulcerative, and anticancer agents, which are expected to find their ways to the clinical setting sooner or later. Due to the role of structural moieties in determining the biological behaviors of benzimidazole derivatives, we explored the structure-activity relationship (SAR) of these compounds to further expand the scope of design of and research on new drugs against H. pylori-related diseases.

Item Type: Article
Keywords: antibacterial activity anticancer activity benzimidazole derivatives gastric cancer gastric ulcer gastritis Helicobacter pylori structure-activity relationship analysis biological evaluation potent inhibitors molecular docking urease agents anticancer design antioxidant copper(ii) resistance Pharmacology & Pharmacy
Page Range: pp. 930-943
Journal or Publication Title: Fundamental & Clinical Pharmacology
Journal Index: ISI
Volume: 36
Number: 6
Identification Number:
ISSN: 0767-3981
Depositing User: مهندس مهدی شریفی

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