Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The role of polybrominated diphenyl ethers in the induction of cancer: a systematic review of insight into their mechanisms

Mon Jul 15 17:08:08 2024

(2023) The role of polybrominated diphenyl ethers in the induction of cancer: a systematic review of insight into their mechanisms. Environmental Science and Pollution Research. pp. 9271-9289. ISSN 0944-1344

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Environmental pollution caused by persistent organic pollutants (POPs) has increased the challenge for the scientific communities. Polybrominated diphenyl ethers (PBDEs), classified as POPs, are widely applied in various materials as brominated flame retardants (BFRs). Because of the nature of these chemical compounds including toxicity, stability, and capability to bioaccumulate and biomagnify, PBDEs have posed a great challenge and risk to human health and wildlife. Therefore, the side effects of exposure to PBDEs as ubiquitous pollutants in the environment on cancer progression were investigated using a systematic review (SR) survey. To achieve this goal, forty studies were considered after defining the search terms and inclusion criteria, and/or exclusion criteria; the eligible records were collected from the international bibliographic databases. Based on the findings of the reviewed records, environmental exposure to the BFRs including PBDEs has a positive association with different mechanisms that induce cancer progression. However, the findings of the reviewed studies were not totally consistent with the mode of action and side effects are yet to be fully elucidated. Several articles have reported that BFRs can be carcinogenic and induce epithelial to mesenchymal transition via different mechanisms. The main mode of action involved in the environmental exposure to BFRs and the risk of cancer progression is endoplasmic reticulum and oxidative stress (OS). Generally, the imbalance of antioxidant mechanisms, reactive nitrogen species (RNSs) and reactive oxygen species (ROSs), during damage in cells, and stress caused OS, which increases tumorigenesis via multiple mechanisms, such as DNA damage, inflammation, and angiogenesis.

Item Type: Article
Noorimotlagh, Z.UNSPECIFIED
Keywords: Polybrominated diphenyl ethers Persistent organic pollutants Oxidative stress Brominated flame retardants Cancer progression Environmental exposure epithelial-mesenchymal transition brominated flame retardants polychlorinated-biphenyls oxidative stress thyroid-cancer breast-cancer risk-assessment serum-levels pbdes cells Environmental Sciences & Ecology
Page Range: pp. 9271-9289
Journal or Publication Title: Environmental Science and Pollution Research
Journal Index: ISI
Volume: 30
Number: 4
Identification Number:
ISSN: 0944-1344
Depositing User: مهندس مهدی شریفی

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