Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Association of the ACE2-Angiotensin1-7-Mas axis with lung damage caused by cigarette smoke exposure: a systematic review

Fri Jul 19 04:13:13 2024

(2023) Association of the ACE2-Angiotensin1-7-Mas axis with lung damage caused by cigarette smoke exposure: a systematic review. Reviews on Environmental Health. p. 9. ISSN 0048-7554

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Through the Mas receptor, angiotensin-(1-7) Ang-(1-7) has been shown to have a key role in the development of lung inflammation. This systematic review (SR) sought to identify the relationship between lung damage brought on by exposure to cigarette smoke (CS) and the ACE2-Ang-(1-7)-Mas pathway. In this investigation, relevant keywords were used to search PubMed (MEDLINE), Scopus (Elsevier), and Institute for Scientific Information (ISI) Web of Science up to December 2022. Nine studies were chosen because they satisfied the inclusion/exclusion criteria. The majority of research concluded that exposure to CS increased the risk of lung damage. Smoking cigarettes is the main cause of COPD because it causes massive amounts of reactive oxygen and nitrogen species to enter the lungs, which stimulate the production of inflammatory cytokines like IL-1 beta, IL-6, and TNF-alpha, as well as the invasion of inflammatory cells like neutrophils and macrophages. These findings support the renin-angiotensin system's (RAS) involvement in the pathophysiology of smoking-induced damage. Additionally, via stimulating pro-inflammatory mediators, aberrant RAS activity has been linked to lung damage. Lung inflammation's etiology has been shown to be significantly influenced by the protective known RAS arm ACE2-Ang-(1-7)-Mas. In conclusion, these are important for informing policymakers to pass legislation limiting the use of smoking and other tobacco to prevent their harmful effects.

Item Type: Article
Kaffashian, M. R.UNSPECIFIED
Keywords: ACE2 Angiotensin1-7 cigarette smoke lung damage Mas receptor Environmental Sciences & Ecology Public, Environmental & Occupational Health
Page Range: p. 9
Journal or Publication Title: Reviews on Environmental Health
Journal Index: ISI
Identification Number:
ISSN: 0048-7554
Depositing User: مهندس مهدی شریفی

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