Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Amelioration of amyloid beta (A beta 1-40) neurotoxicity by administration of silibinin; a behavioral and biochemical assessment

Mon Feb 26 03:52:23 2024

(2023) Amelioration of amyloid beta (A beta 1-40) neurotoxicity by administration of silibinin; a behavioral and biochemical assessment. Iranian Journal of Basic Medical Sciences. pp. 791-798. ISSN 2008-3866

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Abstract

Objective(s): Alzheimer's disease (AD), the most common cause of dementia, is one of the leading causes of morbidity and death in the world. Currently, treatment mostly used to slow down the disease progression. Herbal remedies are considered by many in the community as a natural and safe treatment with fewer side effects. Silibinin, the active ingredient of Silybum marionum, has anti-oxidant, neurotrophic and neuroprotective characteristics. Therefore, here, the effect of different doses of Silibinin extract on oxidative stress and expression of neurotrophic factors was investigated.Materials and Methods: Forty eight male Wistar rats were randomly divided into sham, lesion; A beta 140 injection, lesion-treatment; A beta 1-40 injection followed by different doses of silibinin (50, 100, 200 mg / kg) through gavage and lesion-vehicle group; A beta 1-40 injection + vehicle of silibinin. Morris water Maze (MWM) was done 28 days after the last treatment. Hippocampal tissue was removed for biochemical analysis. Production of nitric oxide (NO) and reactive oxygen species (ROS), expression of BDNF/VEGF and cell viability were measured using Griess, fluorimetry, Western blotting and MTT techniques.Results: Different concentrations of silibinin improved behavioral performance in animals. Higher doses of Silibinin could improve memory and learning function through MWM. Also, increasing the concentration of silibinin resulted in decreased ROS and NO production in a dose-dependent manner.Conclusion: Consequently, silibinin may act as a potential candidate for alleviating symptoms of AD.

Item Type: Article
Creators:
CreatorsEmail
Alihosseini, T.UNSPECIFIED
Azizi, M.UNSPECIFIED
Abbasi, N.UNSPECIFIED
Mohammadpour, S.UNSPECIFIED
Bagheri, M.UNSPECIFIED
Keywords: Alzheimer's disease Amyloid BDNF Oxidative stress Silibinin VEGF oxidative stress cerebral-ischemia silymarin neurons rats Research & Experimental Medicine Pharmacology & Pharmacy
Divisions:
Page Range: pp. 791-798
Journal or Publication Title: Iranian Journal of Basic Medical Sciences
Journal Index: ISI
Volume: 26
Number: 7
Identification Number: https://doi.org/10.22038/ijbms.2023.66831.14665
ISSN: 2008-3866
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4323

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