Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

COMPARISON OF THE EFFECT OF SILDENAFIL AND TADALAFIL ON PULMONARY HYPERTENSION ASSOCIATED WITH HEMODYNAMICALLY SIGNIFICANT PDAS TREATMENT OF PULMONARY HYPERTENSION IN HS-PDA PATIENTS

Thu May 23 02:51:26 2024

(2022) COMPARISON OF THE EFFECT OF SILDENAFIL AND TADALAFIL ON PULMONARY HYPERTENSION ASSOCIATED WITH HEMODYNAMICALLY SIGNIFICANT PDAS TREATMENT OF PULMONARY HYPERTENSION IN HS-PDA PATIENTS. Journal of Pharmaceutical Negative Results. pp. 3266-3274. ISSN 09769234 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Objective: Treating the hemodynamically significant patent ductus arteriosus (hs-PDA) includes conservative therapy besides using non-steroidal anti-inflammatory drugs (NSAIDs) and acetaminophen. In addition, the pulmonary arterial pressure increases in hs-PDA. It is not clear whether the drugs used in acute pulmonary arterial hypertension (PAH) can improve the hs-PDA or not. This study evaluates the effect of anti-PAH drugs, sildenafil and tadalafil on patients with hs-PDA and PAH. Methods: Neonates with hs-PDA and PAH diagnosis are included in this triple-blinded clinical randomized trial study. The patients are assigned to group A (tadalafil + acetaminophen), B (sildenafil + acetaminophen), and C (acetaminophen alone). The patients were evaluated by their echocardiography findings, before and after therapy. Results: Overall, 96 patients were included in this study, 32 for each group. The patients were match for all of the demographic data. All patients had improved echocardiography parameters, except for the TAPSE and MPA diameter for tadalafil patients. On the other hand, the RVEDd and RVESd were improved better in tadalafil patients, in comparison with the sildenafil group (p = 0.012 and 0.022, respectively). There was no significant difference in other echocardiography parameters or the adverse effects. Conclusions: Using anti-PAH drugs such as tadalafil and sildenafil to hs-PDA patients with PAH does not have additional effect to the acetaminophen. Tadalafil and sildenafil did not vary in efficacy and side effects. Despite the safety of adding anti-PAH drugs such as sildenafil and tadalafil, the acetaminophen itself can reduce the pulmonary pressure by closing the patent duct. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Mazouri, A.UNSPECIFIED
Radgoodarzi, M.UNSPECIFIED
Zohrevandi, Z.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Taherifard, P.UNSPECIFIED
Keywords: Acetaminophen Echocardiography Hemodynamically Significant PDA Patent Ductus Arteriosus Pulmonary Arterial Hypertension Sildenafil Tadalafil paracetamol Apgar score Article birth weight comparative study conservative treatment controlled study demographics female gestational age heart right ventricle hemodynamics human lung artery pressure major clinical study male newborn oxygen therapy pulmonary hypertension randomized controlled trial single drug dose
Divisions:
Page Range: pp. 3266-3274
Journal or Publication Title: Journal of Pharmaceutical Negative Results
Journal Index: Scopus
Volume: 13
Identification Number: https://doi.org/10.47750/pnr.2022.13.S08.401
ISSN: 09769234 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4312

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