Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Effects of Vasodepressor vs. Vasopressor Arms of Renin Angiotensin System on Renal Hemodynamic Regulation in Renal Ischemia-Reperfusion Injury; Sex Difference

Wed Feb 28 23:20:11 2024

(2022) Effects of Vasodepressor vs. Vasopressor Arms of Renin Angiotensin System on Renal Hemodynamic Regulation in Renal Ischemia-Reperfusion Injury; Sex Difference. Journal of Isfahan Medical School. pp. 262-271. ISSN 10277595 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

The exact mechanisms involved in acute renal injury (AKI) due to renal ischemia-reperfusion (IR) are not fully understood, although it has been shown that the renin-angiotensin system (RAS) may play an important role in IR-associated AKI. RAS is considered as one of the most important vasoactive systems of endocrine, paracrine and intracrine, which is important in the physiological regulation of cardiovascular function, blood pressure, fluid and electrolytes balance. This system exerts a set of beneficial or adverse vascular and renal effects. The two main arms of RAS include "ACE, angiotensin II, AT1 receptor" (vasoconstrictor arm) and "ACE2, angiotensin 1-7, AT2 receptor and Mas receptor" (vasodilator arm). IR and its outputs have been reported to be sex-dependent. On the other hand, systemic and local RAS function in the regulation of renal hemodynamics can also be affected by gender. In fact, sex and sex hormones affect sensitivity to angiotensin II and angiotensin 1-7. This review article examines the role of RAS receptors of the new vasopressor arm versus the classic vasopressor arm and their function interference, as well as sex differences and it's influence on renal blood flow in renal IR Injury. © 2022 Isfahan University of Medical Sciences(IUMS). All rights reserved.

Item Type: Article
Creators:
CreatorsEmail
Karimi, F.UNSPECIFIED
Safari, T.UNSPECIFIED
Nematbakhsh, M.UNSPECIFIED
Maspi, N.UNSPECIFIED
Maleki, M.UNSPECIFIED
Keywords: Angiotensin Ischemia Receptors Renal Circulation Renin-Angiotensin System Reperfusion injury Sex Characteristics angiotensin 1 receptor angiotensin 2 receptor angiotensin converting enzyme 2 angiotensin II angiotensin1-7 hypertensive factor MAS receptor sex hormone vasoconstrictor agent vasodilator agent blood pressure cardiovascular function electrolyte balance human kidney blood flow kidney injury renal ischemia reperfusion injury renin angiotensin aldosterone system Review sex difference vasomotor system
Divisions:
Page Range: pp. 262-271
Journal or Publication Title: Journal of Isfahan Medical School
Journal Index: Scopus
Volume: 40
Number: 668
Identification Number: https://doi.org/10.48305/jims.v40.i668.0262
ISSN: 10277595 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4306

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