Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Evans syndrome in the course of COVID-19 infection; essentials and approaches

Sat Apr 20 22:49:04 2024

(2022) Evans syndrome in the course of COVID-19 infection; essentials and approaches. Iranian Journal of Blood and Cancer. pp. 32-40. ISSN 20084595 (ISSN)

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Redundant studies proved coronavirus infection results from a defect in a suitable immune response that may exacerbate immune-inflammatory reactions like cytokine storm and autoimmunity. Evans syndrome (ES) is a rare chronic autoimmune disease that distinguishes it from autoimmune hemolytic anemia (AIHA) and immune thrombocytopenic purpura (ITP). Reports have shown significant differences in immune cells and laboratory parameters in Evans syndrome/COVID-19 co-infected patients. Also, the contribution between autoimmune diseases and SARS-CoV-2 infection could result in immune response disequilibrium that considers a possible mechanism for ES development. Moreover, we will briefly explain the double-edged sword role of immunosuppressive drugs in Evans syndrome/ COVID-19 co-infected patients. Generally, the pathophysiology of SARS-CoV-2 in hematologic autoimmune disorders progression, particularly ES, remains unclear, but some investigations explain the COVID-19 infection mechanism in the mentioned disorders development. The purpose of the current study is to look at the coronavirus effects on Evans syndrome aggravation, the immune cells and laboratory markers alterations in Evans syndrome/COVID-19 co-infected patients, the coronavirus effects on Evans syndrome patients during their pregnancy, and the Evans syndrome / COVID-19 co-infected patient management. © 2022, Iranian Pediatric Hematology and Oncology Society. All rights reserved.

Item Type: Article
Pooresmaeil, N.UNSPECIFIED
Keywords: Autoimmune disease Coronavirus COVID-19 Evans syndrome SARS-CoV-2 alemtuzumab cyclophosphamide cyclosporine cytokine receptor affecting agent immunoglobulin mycophenolate mofetil prednisolone prednisone rituximab romiplostim anisocytosis autoimmune hemolytic anemia autoimmune neutropenia coronavirus disease 2019 erythrocyte disorder hematologic disease human idiopathic thrombocytopenic purpura immune response iron deficiency anemia leukocytosis pathophysiology polychromasia reticulocyte Review Severe acute respiratory syndrome coronavirus 2 thrombocytopenia
Page Range: pp. 32-40
Journal or Publication Title: Iranian Journal of Blood and Cancer
Journal Index: Scopus
Volume: 14
Number: 3
ISSN: 20084595 (ISSN)
Depositing User: مهندس مهدی شریفی

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