Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis

Wed May 22 12:32:11 2024

(2016) The Relationship between Zinc Levels and Autism: A Systematic Review and Meta-analysis. Iranian Journal of Child Neurology. pp. 1-9. ISSN 1735-4668

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Objective Autism is a complex behaviorally defined disorder. There is a relationship between zinc (Zn) levels in autistic patients and development of pathogenesis, but the conclusion is not permanent. Materials & Methods The present study conducted to estimate this probability using meta-analysis method. In this study, Fixed Effect Model, twelve articles published from 1978 to 2012 were selected by searching Google scholar, PubMed, ISI Web of Science, and Scopus and information were analyzed. I-2 statistics were calculated to examine heterogeneity. The information was analyzed using R and STATA Ver. 12.2. Results There was no significant statistical difference between hair, nail, and teeth Zn levels between controls and autistic patients: -0.471 95% confidence interval (95% CI): -1.172 to 0.231. There was significant statistical difference between plasma Zn concentration and autistic patients besides healthy controls: -0.253 (95% CI: -0.498 to -0.007). Using a Random Effect Model, the overall Integration of data from the two groups was -0.414 (95% CI: -0.878 to -0.051). Conclusion Based on sensitivity analysis, zinc supplements can be used for the nutritional therapy for autistic patients.

Item Type: Article
Mohamadkhani, A.UNSPECIFIED
Keywords: Zinc concentration Autism Spectrum Disorders Meta-analysis spectrum disorders children copper hair selenium minerals Neurosciences & Neurology
Page Range: pp. 1-9
Journal or Publication Title: Iranian Journal of Child Neurology
Journal Index: ISI
Volume: 10
Number: 4
ISSN: 1735-4668
Depositing User: مهندس مهدی شریفی

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