Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

Green decorated gold nanoparticles on magnetic nanoparticles mediated by Calendula extract for the study of preventive effects in streptozotocin-induced gestational diabetes mellitus rats

Thu Apr 18 23:49:56 2024

(2023) Green decorated gold nanoparticles on magnetic nanoparticles mediated by Calendula extract for the study of preventive effects in streptozotocin-induced gestational diabetes mellitus rats. Inorganic Chemistry Communications. ISSN 13877003 (ISSN)

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Official URL: https://www.scopus.com/inward/record.uri?eid=2-s2....

Abstract

Herein, a bio-inspired synthesis of AuNPs immobilized magnetic ferrite nanocomposite has been demonstrated to be templated over Calendula persica flower extract. The plant phytomolecules facilitated the eco-friendly reduction and stabilization of the Fe3O4/Au hybrid nanomaterial. Thereafter, it was characterized by a range of analytical methods like SEM, TEM, EDX, elemental mapping, VSM, XRD and ICP-OES. In vivo design, the model of gestational diabetes mellitus rats were established with streptozotocin by intraperitoneal injection. Model rats were randomly divided into Fe3O4/AuNPs 20 μg/kg group, 40 μg/kg group, 80 mg/kg group, gestational diabetes mellitus group and normal pregnancy group (n = 15). Fe3O4/AuNPs were applied by intragastric administration for 25 days. On the last day, serum levels of samples blood Glucose, ALT (alanine aminotransferase), AST (aspartate aminotransferase) and ALP (alkalinephosphatase) enzymes were measured. After tissue processing, 5 μm sections of the liver were prepared and the total volume of the liver, hepatocytes, sinusoids, portal vein, central vein, hepatic arteries and bile ducts were estimated. Fe3O4/AuNPs could decrease the raised levels of AST and ALP enzymes in a dose-dependent manner. The fasting blood glucose level decreased in gestational diabetes rats treated with Fe3O4/AuNPs as compared to the model group. The volume of the hepatocytes and sinusoids which was increased significantly by administration of streptozotocin, show a significant decrease after the treatment of a high dose of Fe3O4/AuNPs. The volume of the portal vein and bile ducts did not show significant changes in experimental groups, but the volume of the central vein and hepatic arteries indicated changes in Fe3O4/AuNPs groups. The present research demonstrates the hepatoprotective and antidiabetic properties of the AuNPs, offering to use as a hepatoprotective and antidiabetic supplement for preventing gestational diabetes mellitus. © 2023 Elsevier B.V.

Item Type: Article
Creators:
CreatorsEmail
Ma, H.UNSPECIFIED
Mahdi Zangeneh, M.UNSPECIFIED
Zangeneh, A.UNSPECIFIED
Veisi, H.UNSPECIFIED
Hemmati, S.UNSPECIFIED
Pirhayati, M.UNSPECIFIED
Karmakar, B.UNSPECIFIED
Keywords: Calendula extract Gestational diabetes mellitus Gold Liver Magnetic Streptozotocin
Divisions:
Journal or Publication Title: Inorganic Chemistry Communications
Journal Index: Scopus
Volume: 151
Identification Number: https://doi.org/10.1016/j.inoche.2023.110633
ISSN: 13877003 (ISSN)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4281

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