Repository of Research and Investigative Information

Repository of Research and Investigative Information

Ilam University of Medical Sciences

The First Report of Iranian Registry of Patients with Spinal Muscular Atrophy

Sat Apr 20 14:44:16 2024

(2023) The First Report of Iranian Registry of Patients with Spinal Muscular Atrophy. Journal of neuromuscular diseases. pp. 211-225. ISSN 2214-3602 (Electronic)

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Official URL: https://www.ncbi.nlm.nih.gov/pubmed/36776076

Abstract

BACKGROUND: Insufficient amounts of survival motor neuron protein is leading to one of the most disabling neuromuscular diseases, spinal muscular atrophy (SMA). Before the current study, the detailed characteristics of Iranian patients with SMA had not been determined. OBJECTIVE: To describe the key demographic, clinical, and genetic characteristics of patients with SMA registered in the Iranian Registry of SMA (IRSMA). METHODS: IRSMA has been established since 2018, and the demographic, clinical, and genetic characteristics of patients with SMA were recorded according to the methods of treat neuromuscular disease (TREAT-NMD) project. RESULTS: By October 1, 2022, 781 patients with 5q SMA were registered. Of them, 164 patients died, the majority of them had SMA type 1 and died during the first 20 months of life. The median survival of patients with type 1 SMA was 23 months. The consanguinity rate in 617 alive patients was 52.4, while merely 24.8 of them had a positive family history. The most common type of SMA in live patients was type 3. Morbidities were defined as having scoliosis (44.1), wheelchair dependency (36.8), tube feeding (8.1), and requiring mechanical ventilation (9.9). Most of the registered patients had a homozygous deletion of SMN1, while the frequency of patients with higher copy numbers of SMN2, was less in more severe types of the disease. Earlier onset of the disease was significantly seen in patients with lower copy numbers of SMN2. The neuronal apoptosis inhibitory protein (NAIP) gene deletion was associated with a higher incidence of more severe types of SMA, higher dependency on ventilators, tube feeding, and earlier onset of the disease. CONCLUSIONS: The IRSMA is the first established Iranian nationwide registry of patients with SMA. Using this registry, decision-makers, researchers, and practitioners can precisely understand the epidemiology, characteristics, and genetics of patients with SMA in Iran.

Item Type: Article
Creators:
CreatorsEmail
Mansouri, V.UNSPECIFIED
Heidari, M.UNSPECIFIED
Bemanalizadeh, M.UNSPECIFIED
Azizimalamiri, R.UNSPECIFIED
Nafissi, S.UNSPECIFIED
Akbari, M. G.UNSPECIFIED
Barzegar, M.UNSPECIFIED
Moayedi, A. R.UNSPECIFIED
Badv, R. S.UNSPECIFIED
Mohamadi, M.UNSPECIFIED
Tavasoli, A. R.UNSPECIFIED
Amirsalari, S.UNSPECIFIED
Khajeh, A.UNSPECIFIED
Inaloo, S.UNSPECIFIED
Fatehi, F.UNSPECIFIED
Hosseinpour, S.UNSPECIFIED
Babaei, M.UNSPECIFIED
Hosseini, S. A.UNSPECIFIED
Mahdi Hosseiny, S. M.UNSPECIFIED
Fayyazi, A.UNSPECIFIED
Hosseini, F.UNSPECIFIED
Toosi, M. B.UNSPECIFIED
Khosroshahi, N.UNSPECIFIED
Ghabeli, H.UNSPECIFIED
Biglari, H. N.UNSPECIFIED
Kakhki, S. K.UNSPECIFIED
Mirlohi, S. H.UNSPECIFIED
Bidabadi, E.UNSPECIFIED
Mohammadi, B.UNSPECIFIED
Omrani, A.UNSPECIFIED
Sedighi, M.UNSPECIFIED
Vafaee-Shahi, M.UNSPECIFIED
Rasulinezhad, M.UNSPECIFIED
Hoseini, S. M.UNSPECIFIED
Movahedinia, M.UNSPECIFIED
Rezaei, Z.UNSPECIFIED
Karimi, P.UNSPECIFIED
Farshadmoghadam, H.UNSPECIFIED
Anvari, S.UNSPECIFIED
Yaghini, O.UNSPECIFIED
Nasiri, J.UNSPECIFIED
Zamani, G.UNSPECIFIED
Ashrafi, M. R.UNSPECIFIED
Keywords: Humans Iran Homozygote Sequence Deletion *Muscular Atrophy, Spinal/genetics *Spinal Muscular Atrophies of Childhood/genetics Registries Neuronal apoptosis inhibitory protein Registry Spinal muscular atrophy
Divisions:
Page Range: pp. 211-225
Journal or Publication Title: Journal of neuromuscular diseases
Journal Index: Pubmed
Volume: 10
Number: 2
Identification Number: https://doi.org/10.3233/JND-221614
ISSN: 2214-3602 (Electronic)
Depositing User: مهندس مهدی شریفی
URI: http://eprints.medilam.ac.ir/id/eprint/4260

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